Molecular Epidemiology of Sapovirus in Children Living in the Northwest Amazon Region

Sapovirus is an important etiological agent of acute gastroenteritis (AGE), mainly in children under 5 years old living in lower-income communities. Eighteen identified sapovirus genotypes have been observed to infect humans. The aim of this study was to identify sapovirus genotypes circulating in t...

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Bibliographic Details
Published in:Pathogens (Basel) 2021-07, Vol.10 (8), p.965
Main Authors: Moraes, Marcia Terezinha Baroni de, Leitão, Gabriel Azevedo Alves, Olivares, Alberto Ignácio Olivares, Xavier, Maria da Penha Trindade Pinheiro, Bispo, Romanul de Souza, Sharma, Sumit, Leite, José Paulo Gagliardi, Svensson, Lennart, Nordgren, Johan
Format: Article
Language:English
Subjects:
Age
Amazon region
Antigens
Blood groups
Children
Epidemiology
Etiology
Gastroenteritis
Genomes
Genotype & phenotype
Genotypes
histo-blood group antigen
Infections
Low income groups
Medicin och hälsovetenskap
Phylogenetics
Phylogeny
Proteins
Rainforests
RNA polymerase
Sapovirus
Tourism
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Summary:Sapovirus is an important etiological agent of acute gastroenteritis (AGE), mainly in children under 5 years old living in lower-income communities. Eighteen identified sapovirus genotypes have been observed to infect humans. The aim of this study was to identify sapovirus genotypes circulating in the Amazon region. Twenty-eight samples were successfully genotyped using partial sequencing of the capsid gene. The genotypes identified were GI.1 ( = 3), GI.2 ( = 7), GII.1 ( = 1), GII.2 ( = 1), GII.3 ( = 5), GII.5 ( = 1), and GIV.1 ( = 10). The GIV genotype was the most detected genotype (35.7%, 10/28). The phylogenetic analysis identified sapovirus genotypes that had no similarity with other strains reported from Brazil, indicating that these genotypes may have entered the Amazon region via intense tourism in the Amazon rainforest. No association between histo-blood group antigen expression and sapovirus infection was observed.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10080965