Cell Reprogramming for Regeneration and Repair of the Nervous System

A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a p...

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Bibliographic Details
Published in:Biomedicines 2022-10, Vol.10 (10), p.2598
Main Authors: Clark, Isaac H, Roman, Alex, Fellows, Emily, Radha, Swathi, Var, Susanna R, Roushdy, Zachary, Borer, Samuel M, Johnson, Samantha, Chen, Olivia, Borgida, Jacob S, Steevens, Aleta, Shetty, Anala, Strell, Phoebe, Low, Walter C, Grande, Andrew W
Format: Article
Language:English
Subjects:
Alzheimer's disease
Analysis
Cell division
cell-reprograming
CRISPR
Design
Fibroblasts
Gene expression
gene therapies
Genes
Genetic engineering
Genetic vectors
Genomes
Injuries
Nervous system
Nervous system diseases
neuro-regeneration
Neurological diseases
Neurons
Parkinson's disease
Plasmids
Population studies
Proteins
Regeneration
Review
Stem cells
Success
Tetracycline
Tetracyclines
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Summary:A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10102598