Collagen-Based Hydrogels for the Eye: A Comprehensive Review

Collagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical...

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Bibliographic Details
Published in:Gels 2023-08, Vol.9 (8), p.643
Main Authors: Rana, Dhwani, Desai, Nimeet, Salave, Sagar, Karunakaran, Bharathi, Giri, Jyotsnendu, Benival, Derajram, Gorantla, Srividya, Kommineni, Nagavendra
Format: Article
Language:English
Subjects:
Bioavailability
Biocompatibility
Biological properties
biomedical applications
Blood vessels
Cartilage
Collagen
Connective tissue
Crosslinking
drug delivery
Drug delivery systems
Drugs
Extracellular matrix
eye
Fish
hydrogel
Hydrogels
Ophthalmology
Phase transitions
Polymers
Proteins
Quality control
Quality management
Review
Tendons
Tensile strength
Vehicles
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Summary:Collagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical isolation and purification steps are discussed, emphasizing their pivotal role in preparing collagen for biomedical use. To ensure collagen quality and purity, and the suitability of collagen for targeted applications, a comprehensive characterization and quality control are essential, encompassing assessments of its physical, chemical, and biological properties. Also, various cross-linking collagen methods have been examined for providing insight into this crucial process. This comprehensive review delves into every facet of collagen and explores the wide-ranging applications of collagen-based hydrogels, with a particular emphasis on their use in drug delivery systems and their potential in diverse biomedical interventions. By consolidating current knowledge and advancements in the field, this review aims to provide a detailed overview of the utilization of engineered collagen-based hydrogels in ocular therapeutics.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels9080643