Cardiopulmonary work up of patients with and without fatigue 6 months after COVID-19

The pathogenesis of long-Covid symptoms remains incompletely understood. Therefore, we aimed to determine cardiopulmonary limitations 6 months after surviving COVID-19 using pulmonary function tests, echocardiographic studies to the point of analysis of global-longitudinal-strain (GLS), which descri...

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Bibliographic Details
Published in:Scientific reports 2022-10, Vol.12 (1), p.18038-10, Article 18038
Main Authors: Thiele, Kirsten, Balfanz, Paul, Müller, Tobias, Hartmann, Bojan, Spiesshoefer, Jens, Grebe, Julian, Müller-Wieland, Dirk, Marx, Nikolaus, Dreher, Michael, Daher, Ayham
Format: Article
Language:English
Subjects:
692/1807/1486
692/1807/1809
Coronaviruses
COVID-19
Fatigue
Fatigue - complications
Heart
Humanities and Social Sciences
Humans
Long COVID
Mobility
multidisciplinary
Myocardium
Post-Acute COVID-19 Syndrome
Quality of Life
Respiratory function
Science
Science (multidisciplinary)
Stroke Volume
Ventricle
Ventricular Dysfunction, Left
Ventricular Function, Left
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Summary:The pathogenesis of long-Covid symptoms remains incompletely understood. Therefore, we aimed to determine cardiopulmonary limitations 6 months after surviving COVID-19 using pulmonary function tests, echocardiographic studies to the point of analysis of global-longitudinal-strain (GLS), which describes the cycling myocardium deformation and provides better data on left ventricular (LV) dysfunction than LV ejection fraction (LVEF), and validated questionnaires. Overall, 60 consecutive hospitalized patients were included (61 ± 2 years, 40% treated in the ICU). At follow-up (194 ± 3 days after discharge), fatigue was the most prevalent symptom (28%). Patients with fatigue were more symptomatic overall and characterized by worse quality of life (QoL) scores compared to patients without fatigue (all p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-22876-9