Microwave-enhanced cross-coupling reactions involving alkynyltrifluoroborates with aryl bromides

Palladium-catalyzed alkynylation has emerged as one of the most reliable methods for the synthesis of alkynes which are often used in natural product syntheses and material science. An efficient method for coupling alkynyltrifluoroborates with various aryl bromides in the presence of a palladium cat...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2013-01, Vol.18 (2), p.1755-1761
Main Authors: Coltuclu, Vitali, Dadush, Eric, Naravane, Abhijit, Kabalka, George W
Format: Article
Language:English
Subjects:
alkynes
BASIC BIOLOGICAL SCIENCES
Borates - chemistry
Bromides - chemistry
Chemistry, Organic - methods
Chromatography
coupling reactions
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
microwave
Microwaves
Natural products
organotrifluoroborates
Palladium
Potassium
Reagents
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Summary:Palladium-catalyzed alkynylation has emerged as one of the most reliable methods for the synthesis of alkynes which are often used in natural product syntheses and material science. An efficient method for coupling alkynyltrifluoroborates with various aryl bromides in the presence of a palladium catalyst has been developed using microwave irradiation. The microwave reactions are rapid and efficient.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18021755