Non-Clear Cell Renal Cell Carcinoma: Molecular Pathogenesis, Innovative Modeling, and Targeted Therapeutic Approaches

Non-clear cell renal cell carcinomas (nccRCC) are a diverse group of kidney cancers with histopathologically and genetically heterogeneous features. About 25% of renal cell carcinomas (RCCs) are nccRCC types. The management and treatment of nccRCCs are rather limited, and the data are often estimate...

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Bibliographic Details
Published in:International journal of translational medicine 2022-11, Vol.2 (4), p.555-573
Main Authors: Khoshdel Rad, Niloofar, Vahidyeganeh, Maryam, Mohammadi, Mahsa, Shpichka, Anastasia, Timashev, Peter, Hossein-Khannazer, Nikoo, Vosough, Massoud
Format: Article
Language:English
Subjects:
Chromosomes
collecting duct carcinoma
Cytoplasm
Genes
Growth factors
Histology
hybrid oncocytic tumors
Kidney cancer
Medical prognosis
Metastasis
Mutation
papillary renal carcinoma
Pathogenesis
Patients
Physiology
renal medullary cell carcinoma
Transcription factors
Tumors
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Summary:Non-clear cell renal cell carcinomas (nccRCC) are a diverse group of kidney cancers with histopathologically and genetically heterogeneous features. About 25% of renal cell carcinomas (RCCs) are nccRCC types. The management and treatment of nccRCCs are rather limited, and the data are often estimated from studies in the more common clear cell renal cell carcinoma (ccRCC). Each subtype has its own distinctive biological and therapeutic profile. Our knowledge of the underlying biological features of nccRCC has directed and continues to shape the use of novel therapy targeting the main signaling pathways and leading to improved overall survival (OS) of the patients. This review discusses the characteristic molecular features of the major types of nccRCC and current cell-based and animal models for studying them. In the following, we highlighted major signaling pathways and therapeutic approaches for nccRCC patients.
ISSN:2673-8937
2673-8937
DOI:10.3390/ijtm2040042