Antibiotic Exposure in Early Life Increases Risk of Childhood Obesity: A Systematic Review and Meta-Analysis

A number of studies have previously assessed the impact of antibiotic exposure in early life on the risk of childhood obesity, but no systematic assessment is currently available. A systematic review and meta-analysis was performed to comprehensively and quantitatively elucidate the risk of childhoo...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2017-07, Vol.8, p.170-170
Main Authors: Shao, Xiaoqing, Ding, Xiaolian, Wang, Bin, Li, Ling, An, Xiaofei, Yao, Qiuming, Song, Ronghua, Zhang, Jin-An
Format: Article
Language:English
Subjects:
antibiotics
childhood obesity
Endocrinology
meta-analysis
overweight
risk factor
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Summary:A number of studies have previously assessed the impact of antibiotic exposure in early life on the risk of childhood obesity, but no systematic assessment is currently available. A systematic review and meta-analysis was performed to comprehensively and quantitatively elucidate the risk of childhood obesity caused by antibiotic exposure in early life. Literature search was performed in PubMed, Embase, and Web of Science. Random-effect meta-analysis was used to pool the statistical estimates. Fifteen cohort studies involving 445,880 participants were finally included, and all those studies were performed in developed countries. Antibiotic exposure in early life significantly increased risk of childhood overweight [relative risk (RR) = 1.23, 95% confidence interval (CI) 1.13-1.35,  
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2017.00170