Characteristics and serology of pregnant women with cytomegalovirus immunoglobulin G seroconversion during pregnancy in Japan

Investigate the characteristics and serology of pregnant women with cytomegalovirus (CMV) immunoglobulin (Ig)G seroconversion during pregnancy to understand the risk factors associated with primary CMV infection and the occurrence of fetal congenital CMV infection. We retrospectively studied 3202 pr...

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Bibliographic Details
Published in:Taiwanese journal of obstetrics & gynecology 2021-07, Vol.60 (4), p.621-627
Main Authors: Shimada, Kyoko, Toriyabe, Kuniaki, Kitamura, Asa, Morikawa, Fumihiro, Ikejiri, Makoto, Minematsu, Toshio, Nakamura, Haruna, Suga, Shigeru, Ikeda, Tomoaki
Format: Article
Language:English
Subjects:
Congenital cytomegalovirus infection
Immunoglobulin G
Immunoglobulin M
Primary cytomegalovirus infection
Teenagers
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Summary:Investigate the characteristics and serology of pregnant women with cytomegalovirus (CMV) immunoglobulin (Ig)G seroconversion during pregnancy to understand the risk factors associated with primary CMV infection and the occurrence of fetal congenital CMV infection. We retrospectively studied 3202 pregnant women who were CMV IgG-negative in early pregnancy and were retested for IgG in late pregnancy. Characteristics were compared between participants with and without IgG seroconversion, and serological parameters were compared between participants with and without fetal congenital CMV infection. Twenty-six participants showed CMV IgG seroconversion and fifteen showed fetal congenital CMV infection. Seroconversion rates were significantly higher in teens (5.0%) than in older women (20s: 0.8%; 30s and over: 0.6%) (p 
ISSN:1028-4559
DOI:10.1016/j.tjog.2021.05.008