High prevalence of penicillin-nonsusceptible Streptococcus pneumoniae at a community hospital in Oklahoma

During 1997, Oklahoma City's Hospital A reported penicillin-nonsusceptible Streptococcus pneumoniae in almost 67% of isolates. To confirm this finding, all Hospital A S. pneumoniae isolates from October 23, 1997, through February 19, 1998, were tested for antibiotic susceptibility and repeat-te...

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Bibliographic Details
Published in:Emerging infectious diseases 2000-05, Vol.6 (3), p.283-289
Main Authors: Moolenaar, R L, Pasley-Shaw, R, Harkess, J R, Lee, A, Crutcher, J M
Format: Article
Language:English
Subjects:
Adolescent
Adult
bacterial pneumonia
cephalosporin susceptibility
Cohort Studies
Demographic aspects
Drug resistance in microorganisms
Female
Hospitals
Hospitals, Urban
Humans
Laboratories
Male
Microbial Sensitivity Tests
Middle Aged
Oklahoma
Oklahoma - epidemiology
Penicillin Resistance
Penicillins - pharmacology
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
pneumococcal isolates
PNSP
Prevalence
Prospective Studies
resistance
Retrospective Studies
s. pneumoniae
Sentinel Surveillance
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
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Summary:During 1997, Oklahoma City's Hospital A reported penicillin-nonsusceptible Streptococcus pneumoniae in almost 67% of isolates. To confirm this finding, all Hospital A S. pneumoniae isolates from October 23, 1997, through February 19, 1998, were tested for antibiotic susceptibility and repeat-tested at two other hospital laboratories. Medical records of Hospital A patients with invasive S. pneumoniae infections during 1994 through 1997 were also reviewed. These data were compared with 1998 statewide sentinel hospital surveillance data for invasive S. pneumoniae. Of 48 S. pneumoniae isolates from Hospital A during October 23, 1997, through February 19, 1998, 31 (65%) were penicillin-nonsusceptible S. pneumoniae, and 23 (48%) were highly penicillin resistant. Similar prevalences were confirmed at the other hospital laboratories; however, significant interlaboratory differences were noted in the determination of third-generation cephalosporin susceptibility. During 1994 through 1997, a trend toward increasing penicillin nonsusceptibility (p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid0603.000308