Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest and clinical applications. The treatment of vegetable oils with ozone leads to the creation of a reservo...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-01, Vol.25 (2), p.334
Main Authors: Ugazio, Elena, Tullio, Vivian, Binello, Arianna, Tagliapietra, Silvia, Dosio, Franco
Format: Article
Language:English
Subjects:
Administration, Topical
Anti-Bacterial Agents - administration & dosage
Antibacterial activity
Antibiotics
Antifungal agents
Antimicrobial agents
Bacteria
Commercialization
delivery systems
Drug Delivery Systems - methods
Drug resistance
Fatty acids
Gram-positive bacteria
Humans
Infections
Irritation
Microorganisms
Natural products
Odor
Odors
Oils & fats
Olive oil
ozonated oils
Ozone
Ozone - chemistry
Ozonides
Pathogens
Plant Oils - administration & dosage
Review
Side effects
Skin
Skin Diseases - drug therapy
Soft tissues
Textiles
topical anti-infectives
Vegetable oils
Vegetables
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Summary:The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest and clinical applications. The treatment of vegetable oils with ozone leads to the creation of a reservoir of ozone that slowly releases into the skin thanks to the fact that ozone can be held as ozonides of unsaturated fatty acids. Interest in the use of ozonated oils has meant that several ozonated-vegetable-oil-containing products have been commercialized as cosmetic and pharmaceutical agents, and in innovative textile products with antibacterial activity. New approaches to the delivery of ozonated oils have very recently appeared in an attempt to improve their characteristics and reduce drawbacks, such as an unpleasant odor, high viscosity and undesired effects on skin, including irritation and rashes. The present review focuses on the current status of delivery agents that use ozonated oils as antimicrobial agents in topical (dermal, skin, and soft tissues) treatments. Challenges and future opportunities for these delivery systems will also be discussed.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25020334