Predictive and Prognostic Effects of Primary Tumor Size on Colorectal Cancer Survival

Pathologic staging is crucial in colorectal cancer (CRC). Unlike the majority of solid tumors, the current staging model does not use tumor size as a criterion. We evaluated the predictive and prognostic impact of primary tumor size on all stages of CRC. Using the National Cancer Database (NCDB), we...

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Bibliographic Details
Published in:Frontiers in oncology 2021-12, Vol.11, p.728076-728076
Main Authors: Alese, Olatunji B, Zhou, Wei, Jiang, Renjian, Zakka, Katerina, Huang, Zhonglu, Okoli, Chimuanya, Shaib, Walid L, Akce, Mehmet, Diab, Maria, Wu, Christina, El-Rayes, Bassel F
Format: Article
Language:English
Subjects:
colorectal cancer
Oncology
primary tumor size
prognostic factors
survival outcomes
therapy response determinants
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Summary:Pathologic staging is crucial in colorectal cancer (CRC). Unlike the majority of solid tumors, the current staging model does not use tumor size as a criterion. We evaluated the predictive and prognostic impact of primary tumor size on all stages of CRC. Using the National Cancer Database (NCDB), we conducted an analysis of CRC patients diagnosed between 2010 and 2015 who underwent resection of their primary cancer. Univariate and multivariate analyses were used to identify predictive and prognostic factors, Kaplan-Meier analysis and Cox proportional hazards models for association between tumor size and survival. About 61,000 patients met the inclusion criteria. Median age was 63 years and majority of the tumors were colon primary (82.7%). AJCC stage distribution was: I - 20.1%; II - 32.1%; III - 34.7% and IV - 13.1%. The prognostic impact of tumor size was strongly associated with survival in stage III disease. Compared to patients with tumors
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.728076