Tempranillo Grape Extract in Transfersomes: A Nanoproduct with Antioxidant Activity

Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from grape pomace was obtained and characterized qualitatively and quantitatively. The major component...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2022-02, Vol.12 (5), p.746
Main Authors: Asensio-Regalado, Carlos, Alonso-Salces, Rosa María, Gallo, Blanca, Berrueta, Luis A, Era, Benedetta, Pintus, Francesca, Caddeo, Carla
Format: Article
Language:English
Subjects:
Acids
Anthocyanins
antioxidant
Antioxidants
Bioactive compounds
Bioavailability
Chromatography
Colorimetry
Cytotoxicity
Ethanol
Flavonols
Free radicals
Fruits
grape pomace extract
Grapes
Keratinocytes
phospholipid vesicles
Phospholipids
Polyphenols
Skin
skin cells
skin delivery
Vesicles
Wines
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Summary:Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from grape pomace was obtained and characterized qualitatively and quantitatively. The major components found were anthocyanins, flavan-3-ols, and flavonols. To improve the bioavailability of these compounds, the extract was formulated in phospholipid vesicles, namely transfersomes. Spherical unilamellar vesicles around 100 nm each were obtained. The antioxidant activity of both the extract and the transfersomes was evaluated by using colorimetric assays (i.e., DPPH, FRAP, and Folin-Ciocalteu). The cells' viability and the antioxidant activity were assessed in keratinocytes. The results showed that the extract and the transfersomes had no cytotoxic effects and exerted remarkable antioxidant activity, which was more evident in a vesicle formulation. These findings highlighted the potential of the grape pomace extract and the efficacy of the incorporation into phospholipid vesicles.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano12050746