The Therapeutic Efficacy of Punica granatum and Its Bioactive Constituents with Special Reference to Photodynamic Therapy

Punica granatum (P. granatum) is a fruit-bearing tree from the Punicaceae family, indigenous to Iran. This plant has healing qualities that have drawn the interest of the medical community as an alternative treatment for malignancies and non-malignancies. Its healing quality is due to the phytochemi...

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Bibliographic Details
Published in:Plants (Basel) 2022-10, Vol.11 (21), p.2820
Main Authors: Fakudze, Nosipho Thembekile, Aniogo, Eric Chekwube, George, Blassan P., Abrahamse, Heidi
Format: Article
Language:English
Subjects:
anti-osteoarthritis
anticancer
Anticancer properties
antioxidant
Antitumor activity
Cancer
Cell proliferation
Chinese medicine
Constituents
Dysentery
Ellagic acid
Flavonoids
Free radicals
Healing
Health services
Indigenous plants
Kinases
Leprosy
Malignancy
Medical treatment
Osteoarthritis
P. granatum
Phenols
Photodynamic therapy
Phytochemicals
Punica granatum
Review
Seeds
Visibility
Waterborne diseases
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Summary:Punica granatum (P. granatum) is a fruit-bearing tree from the Punicaceae family, indigenous to Iran. This plant has healing qualities that have drawn the interest of the medical community as an alternative treatment for malignancies and non-malignancies. Its healing quality is due to the phytochemicals present in the plant. These include ellagic acid, punicic acid, phenols, and flavonoids. In traditional medicine, P. granatum has been used in treating diseases such as dysentery, bleeding disorders, leprosy, and burns. This review explores the effects of the phytochemical constituents of P. granatum on photodynamic therapy for cancer, chronic inflammation, osteoarthritis, and viral infections. Its antioxidant and antitumor effects play a role in reduced free radical damage and cancer cell proliferation. It was concluded that P. granatum has been used for many disease conditions for a better therapeutic outcome. This paper will give visibility to more studies and expand the knowledge on the potential use of P. granatum in photodynamic cancer treatment.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants11212820