Central post-stroke pain: advances in clinical and preclinical research

Central poststroke pain (CPSP) is a medical complication that arises poststroke and significantly impacts the quality of life and social functioning of affected individuals. Despite ongoing research, the exact pathomechanisms of CPSP remain unclear, and practical treatments are still unavailable. Ou...

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Published in:Stroke and vascular neurology 2024-09, p.svn-2024-003418
Main Authors: Yuan, Xiqian, Hu, Siyuan, Fan, Xiaochong, Jiang, Chao, Xu, Yan, Hao, Ruochen, Xu, Zili, Yu, Yiyang, Rastegar-Kashkooli, Yousef, Huang, Leo, Wang, Tom J, Wang, Qiao, Su, Songxue, Wang, Limin, Wang, Junyang, Wang, Menglu, Kim, Yun Tai, Bhawal, Ujjal K, Wang, Fushun, Zhao, Ting, Wang, Junmin, Chen, Xuemei, Wang, Jian
Format: Article
Language:English
Subjects:
Anxiety
Brain
Brain research
Chronic pain
Deep brain stimulation
Emotions
Females
Hemorrhage
Inflammation
Ischemia
Males
Pathogenesis
Patients
Quality of life
Questionnaires
Review
Spinal cord
Spinal Nerves
Stroke
Transcranial magnetic stimulation
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Summary:Central poststroke pain (CPSP) is a medical complication that arises poststroke and significantly impacts the quality of life and social functioning of affected individuals. Despite ongoing research, the exact pathomechanisms of CPSP remain unclear, and practical treatments are still unavailable. Our review aims to systematically analyse current clinical and preclinical studies on CPSP, which is critical for identifying gaps in knowledge and guiding the development of effective therapies. The review will clarify the clinical characteristics, evaluation scales and contemporary therapeutic approaches for CPSP based on clinical investigations. It will particularly emphasise the CPSP model initiated by stroke, shedding light on its underlying mechanisms and evaluating treatments validated in preclinical studies. Furthermore, the review will not only highlight methodological limitations in animal trials but also offer specific recommendations to researchers to improve the quality of future investigations and guide the development of effective therapies. This review is expected to provide valuable insights into the current knowledge regarding CPSP and can serve as a guide for future research and clinical practice. The review will contribute to the scientific understanding of CPSP and help develop effective clinical interventions.
ISSN:2059-8688
2059-8696
2059-8696
DOI:10.1136/svn-2024-003418