Advanced strategies for constructing interfacial tissues of bone and tendon/ligament

Enthesis, the interfacial tissue between a tendon/ligament and bone, exhibits a complex histological transition from soft to hard tissue, which significantly complicates its repair and regeneration after injury. Because traditional surgical treatments for enthesis injury are not satisfactory, tissue...

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Bibliographic Details
Published in:Journal of Tissue Engineering 2022-01, Vol.13, p.20417314221144714-20417314221144714
Main Authors: Luo, Wangwang, Wang, Yang, Han, Qing, Wang, Zhonghan, Jiao, Jianhang, Gong, Xuqiang, Liu, Yang, Zhang, Aobo, Zhang, Han, Chen, Hao, Wang, Jincheng, Wu, Minfei
Format: Article
Language:English
Subjects:
Growth factors
Ligaments
Regeneration
Regeneration (physiology)
Review
Scaffolds
Tendons
Tissue engineering
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Summary:Enthesis, the interfacial tissue between a tendon/ligament and bone, exhibits a complex histological transition from soft to hard tissue, which significantly complicates its repair and regeneration after injury. Because traditional surgical treatments for enthesis injury are not satisfactory, tissue engineering has emerged as a strategy for improving treatment success. Rapid advances in enthesis tissue engineering have led to the development of several strategies for promoting enthesis tissue regeneration, including biological scaffolds, cells, growth factors, and biophysical modulation. In this review, we discuss recent advances in enthesis tissue engineering, particularly the use of biological scaffolds, as well as perspectives on the future directions in enthesis tissue engineering.
ISSN:2041-7314
2041-7314
DOI:10.1177/20417314221144714