Metalloproteinases and colorectal cancer. Correlation of gene expression and clinical-pathological parameters

Abstract Purpose: To analyze gene and protein expression of metalloproteinases 1, 2, 9, 11 and 16 and their correlation with clinicopathological variables in colorectal adenocarcinoma. Methods: A retrospective study of 114 patients with colorectal adenocarcinoma treated surgically in the period 2006...

Full description

Saved in:
Bibliographic Details
Published in:Acta cirúrgica brasileira 2020-01, Vol.35 (7)
Main Authors: Morini, Sandra Regina, Denadai, Marcos Vinicius, Waisberg, Jaques, Lopes Filho, Gaspar de Jesus, Matos, Delcio, Saad, Sarhan Sydney
Format: Article
Language:English
Subjects:
Colorectal Neoplasms
Extracellular Matrix
Metalloproteases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose: To analyze gene and protein expression of metalloproteinases 1, 2, 9, 11 and 16 and their correlation with clinicopathological variables in colorectal adenocarcinoma. Methods: A retrospective study of 114 patients with colorectal adenocarcinoma treated surgically in the period 2006 to 2008 in Hospital de Câncer de Barretos - Fundação Pio XII. The evaluation of gene expression was performed by RT-PCR, and protein by immunohistochemistry. The analysis of gene expression was classified as overexpressed genes and poorly expressed (fold change of approximately 2, p
ISSN:0102-8650
1678-2674
DOI:10.1590/s0102-865020200070000007