Peripapillary RNFL/vessel density ratio in patients with type2 diabetes without clinical diabetic retinopathy

• Published in: Scientific reports 2022-06, Vol.12 (1), p.9463-9463, Article 9463
• Main Authors: Lee, Min-Woo, Lee, Jong-Wook, Lee, Kook-Hyung, Lee, Young-Hoon, Kim, Jung-Yeul
• Format: Article
• Language: English
• Subjects: 692/308; 692/699/3161; Child, Preschool; Correlation analysis; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetic Retinopathy; Eye; Humanities and Social Sciences; Humans; Microvasculature; multidisciplinary; Nerve Fibers; Neurodegeneration; Optic Disk - blood supply; Patients; Retina; Retinal Ganglion Cells; Retinal Vessels; Retinopathy; Retrospective Studies; Science; Science (multidisciplinary); Tomography, Optical Coherence
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-13567-6

To identify how diabetic retinal neurodegeneration (DRN) and microvascular impairment are affected differently by various factors in type 2 diabetes (T2DM) patients without diabetic retinopathy via the ratio of RNFL thickness/vessel density (RNFL/VD) ratio. In this retrospective cross-sectional study, subjects were divided into two groups: controls (control group) and patients with T2DM (DM group). The RNFL thickness, VD, and RNDL/VD ratio were compared between two groups, and correlation analyses were performed to identify the relationship between the RNFL/VD ratio and various factors. A total of 411 eyes were enrolled: 195 eyes in the control group and 216 eyes in the DM group. The mean RNFL thickness was 95.9 ± 8.6 and 93.7 ± 8.7 μm (P = 0.016), the VD was 18.2 ± 0.7 and 17.6 ± 1.1 mm −1 (P