Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson‘s disease

• Published in: NeuroImage clinical 2020-01, Vol.25, p.102076, Article 102076
• Main Authors: Miloserdov, Kristina, Schmidt-Samoa, Carsten, Williams, Kathleen, Weinrich, Christiane Anne, Kagan, Igor, Bürk, Katrin, Trenkwalder, Claudia, Bähr, Mathias, Wilke, Melanie
• Format: Article
• Language: English
• Subjects: Continuous flash suppression; Misperceptions; Parkinson's disease; Regular; Trial-by-trial variability; Visual hallucinations
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2019.102076

•Parkinson patients with hallucinations exhibit more perceptual errors.•Perceptual errors are due to decrease in perceptual sensitivity and not to response bias.•Parkinson patients with hallucinations exhibit increased performance fluctuations.•Deficits correlate with functional connectivity changes in fronto-parietal networks. Patients with Parkinson's disease (PD) frequently suffer from visual misperceptions and hallucinations, which are difficult to objectify and quantify. We aimed to develop an image recognition task to objectify misperceptions and to assess performance fluctuations in PD patients with and without self-reported hallucinations. Thirty-two non-demented patients with Parkinson's disease (16 with and 16 without self-reported visual hallucinations) and 25 age-matched healthy controls (HC) were tested. Participants performed a dynamic image recognition task with real and scrambled images. We assessed misperception scores and intra-individual variability in recognition times. To gain insight into possible neural mechanisms related to misperceptions and performance fluctuations we correlated resting state network connectivity to the behavioral outcomes in a subsample of Parkinson's disease patients (N = 16). We found that PD patients with self-reported hallucinations (PD-VH) exhibited higher perceptual error rates, due to decreased perceptual sensitivity and not due to changed decision criteria. In addition, PD-VH patients exhibited higher intra-individual variability in recognition times than HC or PD-nonVH patients. Both, misperceptions and intra-individual variability were negatively correlated with resting state functional connectivity involving frontal and parietal brain regions, albeit in partly different subregions. Consistent with previous research suggesting that hallucinations arise from dysfunction in attentional networks, misperception scores correlated with reduced functional connectivity between the dorsal attention and salience network. Intra-individual variability correlated with decreased connectivity between somatomotor and right fronto-parietal networks. We conclude that our task can detect visual misperceptions that are more prevalent in PD-VH patients. In addition, fluctuating visual performance appear to be a signature of PD-VH patients, which might assist further studies of the underlying pathophysiological mechanisms and cognitive processes.