PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations

The aim of our study was to evaluate the properties of different commercially available resorbable collagen membranes for guided bone regeneration, upon addition of plasma rich in growth factors (PRGF). The structural and morphological details, mechanical properties, and enzymatic degradation were i...

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Bibliographic Details
Published in:Applied sciences 2019-03, Vol.9 (5), p.1035
Main Authors: Ratiu, Cristian, Brocks, Marcel, Costea, Traian, Moldovan, Liviu, Cavalu, Simona
Format: Article
Language:English
Subjects:
Advantages
Atomic force microscopy
Biocompatibility
Biomedical materials
Blood platelets
Bone growth
Chemokines
Collagen
Cytokines
Degradation
Fourier transforms
Growth factors
guided bone regeneration
Hematology
Mechanical properties
membrane
Membranes
Microscopy
Modulus of elasticity
Nanoindentation
Plasma
Porosity
Regeneration
Regeneration (physiology)
Thin films
Tissue engineering
Trypsin
Wound healing
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Summary:The aim of our study was to evaluate the properties of different commercially available resorbable collagen membranes for guided bone regeneration, upon addition of plasma rich in growth factors (PRGF). The structural and morphological details, mechanical properties, and enzymatic degradation were investigated in a new approach, providing clinicians with new data in order to help them in a successful comparison and better selection of membranes with respect to their placement and working condition. Particular characteristics such as porosity, fiber density, and surface topography may influence the mechanical behavior and performances of the membranes, as revealed by SEM/AFM and nanoindentation measurements. The mechanical properties and enzymatic degradation of the membranes were analyzed in a comparative manner, before and after PRGF-modification. The changes in Young modulus values are correlated with the ultrastructural properties of each membrane type. The enzymatic (trypsin) degradation test also emphasized that PRGF-modified membranes exhibit a slower degradation compared to the native ones.
ISSN:2076-3417
2076-3417
DOI:10.3390/app9051035