Involvement of Actin and Actin-Binding Proteins in Carcinogenesis

The actin cytoskeleton plays a crucial role in many cellular processes while its reorganization is important in maintaining cell homeostasis. However, in the case of cancer cells, actin and ABPs (actin-binding proteins) are involved in all stages of carcinogenesis. Literature has reported that ABPs...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-10, Vol.9 (10), p.2245
Main Authors: Izdebska, Magdalena, Zielińska, Wioletta, Hałas-Wiśniewska, Marta, Grzanka, Alina
Format: Article
Language:English
Subjects:
ABPs
Actin
Actinin
angiogenesis
Apoptosis
Binding proteins
Cancer
Carcinogenesis
Cell division
Cell proliferation
Cofilin
Cytoskeleton
EMT
Gene expression
Homeostasis
Localization
metastasis
Microfilaments
Observations
Participation
Physiological aspects
Polymerization
Proteins
Review
Vascularization
Wiskott-Aldrich syndrome
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Summary:The actin cytoskeleton plays a crucial role in many cellular processes while its reorganization is important in maintaining cell homeostasis. However, in the case of cancer cells, actin and ABPs (actin-binding proteins) are involved in all stages of carcinogenesis. Literature has reported that ABPs such as SATB1 (special AT-rich binding protein 1), WASP (Wiskott-Aldrich syndrome protein), nesprin, and villin take part in the initial step of carcinogenesis by regulating oncogene expression. Additionally, changes in actin localization promote cell proliferation by inhibiting apoptosis (SATB1). In turn, migration and invasion of cancer cells are based on the formation of actin-rich protrusions (Arp2/3 complex, filamin A, fascin, α-actinin, and cofilin). Importantly, more and more scientists suggest that microfilaments together with the associated proteins mediate tumor vascularization. Hence, the presented article aims to summarize literature reports in the context of the potential role of actin and ABPs in all steps of carcinogenesis.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9102245