Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances

Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged fibrosis usually negatively affects cardiac functi...

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Bibliographic Details
Published in:Frontiers in physiology 2020-05, Vol.11, p.416-416
Main Authors: Fu, Xing, Liu, Qianglin, Li, Chaoyang, Li, Yuxia, Wang, Leshan
Format: Article
Language:English
Subjects:
cardiac disease
cardiac fibroblast
fibrosis
heart
lineage-tracing
Physiology
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Summary:Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged fibrosis usually negatively affects cardiac function and often leads to deleterious consequences. While the development of cardiac fibrosis involves several cell types, the major source of ECM proteins is cardiac fibroblast. The high plasticity of cardiac fibroblasts enables them to quickly change their behaviors in response to injury and transition between several differentiation states. However, the study of cardiac fibroblasts was very difficult due to the lack of specific research tools. The development of cardiac fibroblast lineage-tracing mouse lines has greatly promoted cardiac fibrosis research. In this article, we review the recent cardiac fibroblast lineage-tracing studies exploring the origin of cardiac fibroblasts and their complicated roles in cardiac fibrosis, and briefly discuss the translational potential of basic cardiac fibroblast researches.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2020.00416