Potential of adipose-derived stem cells in muscular regenerative therapies

Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation to find new approaches that could boost regeneration of endogenous myogeni...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2015-07, Vol.7, p.123-123
Main Author: Forcales, Sonia-V
Format: Article
Language:English
Subjects:
Adipose
Adipose tissues
Autografts
Biopsy
Cell differentiation
Cell proliferation
Cèl·lules mare
DNA methylation
Kinases
Medicina regenerativa
Mesenchyme
Morbidity
Muscle
Muscular dystrophy
Myogenesis
Neuroscience
Regeneració (Biologia)
Regeneration
Regeneration (Biology)
Regenerative medicine
Satellite cells
Skeletal muscle
Stem Cells
Stromal cells
Teixit adipós
Therapeutic applications
Transplantation of organs
Transplantation, Autologous
Transplantation, Heterologous
Transplants & implants
Trasplantament d'òrgans
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Summary:Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation to find new approaches that could boost regeneration of endogenous myogenic progenitor populations. In recent years, a lot of effort has been applied to purify, expand and manipulate adult stem cells from muscle tissue. However, this population of endogenous myogenic progenitors in adults is limited and their access is difficult and invasive. Therefore, other sources of stem cells with potential to regenerate muscles need to be examined. An excellent candidate could be a population of adult stromal cells within fat characterized by mesenchymal properties, which have been termed adipose-derived stem cells (ASCs). These progenitor adult stem cells have been successfully differentiated in vitro to osteogenic, chondrogenic, neurogenic and myogenic lineages. Autologous ASCs are multipotent and can be harvested with low morbidity; thus, they hold promise for a range of therapeutic applications. This review will summarize the use of ASCs in muscle regenerative approaches.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2015.00123