Asthma-COPD overlap syndrome in the US: a prospective population-based analysis of patient-reported outcomes and health care utilization

• Published in: International journal of chronic obstructive pulmonary disease 2017-01, Vol.12, p.517-527
• Main Authors: Vaz Fragoso, Carlos A, Murphy, Terrence E, Agogo, George O, Allore, Heather G, McAvay, Gail J
• Format: Article
• Language: English
• Subjects: ACOS; Activities of Daily Living; Adult; Age groups; Aged; Aged, 80 and over; Airway management; Ambulatory Care - economics; Ambulatory Care - statistics & numerical data; Asthma; Asthma - diagnosis; Asthma - economics; Asthma - physiopathology; Asthma - therapy; Bed Rest; Bronchitis; Cardiovascular disease; Care and treatment; Chronic obstructive lung disease; COPD; Cost of Illness; Development and progression; Disability Evaluation; Emergency Medical Services - economics; Emergency Medical Services - statistics & numerical data; Expenditures; Female; Forecasts and trends; Health Resources - economics; Health Resources - statistics & numerical data; Health services utilization; Health Status; healthcare utilization; Hospital Costs; Hospitalization; Households; Humans; Linear Models; Logistic Models; Male; Medical care utilization; Mental health; Middle age; Middle Aged; Mobility; Mobility Limitation; Multivariate Analysis; Odds Ratio; Older people; Original Research; Patient Admission - economics; Patient Reported Outcome Measures; patient-reported outcomes; Population; Prospective Studies; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - economics; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Disease, Chronic Obstructive - therapy; Questionnaires; Risk Assessment; Risk Factors; Smoking; Social Behavior; Surveillance; Treatment Outcome; United States
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/copd.s121223

Prior work suggests that asthma-COPD overlap syndrome (ACOS) has a greater health burden than asthma alone or COPD alone. In the current study, we have further evaluated the health burden of ACOS in a nationally representative sample of the US population, focusing on patient-reported outcomes and health care utilization and on comparisons with asthma alone and COPD alone. Patient-reported outcomes are especially meaningful, as these include functional activities that are highly valued by patients and are the basis for patient-centered care. Using data from the Medical Expenditure Panel Survey (MEPS), we evaluated patient-reported outcomes and health care utilization among participants who were aged 40-85 years and had self-reported, physician-diagnosed asthma or COPD. MEPS administered five rounds of interviews, at baseline and approximately every 6 months over 2.5 years. Patient-reported outcomes included activities of daily living (ADLs), mobility, social/recreational activities, disability days in bed, and health status (Short Form 12, Version 2). Health care utilization included outpatient and emergency department (ED) visits, and hospitalization. Of 3,486 participants with asthma or COPD, 1,585 (45.4%) had asthma alone, 1,294 (37.1%) had COPD alone, and 607 (17.4%) had ACOS. Relative to asthma alone, ACOS was significantly associated with higher odds of prevalent disability in ADLs and limitations in mobility and social/recreational activities (adjusted odds ratios [adjORs]: 1.91-3.98), as well as with higher odds of incident limitations in mobility and social/recreational activities, disability days in bed, and respiratory-based outpatient and ED visits, and hospitalization (adjORs: 1.86-2.35). In addition, ACOS had significantly worse physical and mental health scores than asthma alone ( -values