A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing

Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators suc...

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Bibliographic Details
Published in:Biosensors (Basel) 2023-10, Vol.13 (10), p.914
Main Authors: Yang, Jie, Ding, Ao, Zhou, Jia-Le, Yan, Bing-Yong, Gu, Zhen, Wang, Hui-Feng
Format: Article
Language:English
Subjects:
Bioreactors
Biosensors
Calcium ions
Calibration
capsule sensor
Carbon dioxide
Cell culture
Cell Culture Techniques
Cell growth
Chemical indicators
Chemical properties
Chemical sensors
Contamination
Culture media
Data transmission
Design and construction
Dissolved oxygen
Electrochemical apparatus
Electrochemistry
Electrodes
Identification and classification
In situ measurement
in situ monitoring
Ion-Selective Electrodes
Ions
Magnesium
Management
Metabolism
Metabolites
multichannel
Multichannel communication
Optimization
Self calibration
Sensors
Signal processing
solid-contact ion-selective electrode
wireless sensor network
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Summary:Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K , NH , Na , Ca , and Mg based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios13100914