Loading…
A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing
Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators suc...
Saved in:
| Published in: | Biosensors (Basel) 2023-10, Vol.13 (10), p.914 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c475t-b4e3294dce75211c05db4bf73f344f7276a6e9a0816485b245a6c08524b97b973 |
| container_end_page | |
| container_issue | 10 |
| container_start_page | 914 |
| container_title | Biosensors (Basel) |
| container_volume | 13 |
| creator | Yang, Jie Ding, Ao Zhou, Jia-Le Yan, Bing-Yong Gu, Zhen Wang, Hui-Feng |
| description | Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K
, NH
, Na
, Ca
, and Mg
based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media. |
| doi_str_mv | 10.3390/bios13100914 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_24dbd9556fe94ef3a18fba29a4b08a9b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A771911917</galeid><doaj_id>oai_doaj_org_article_24dbd9556fe94ef3a18fba29a4b08a9b</doaj_id><sourcerecordid>A771911917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-b4e3294dce75211c05db4bf73f344f7276a6e9a0816485b245a6c08524b97b973</originalsourceid><addsrcrecordid>eNpdUk1vGyEQXVWtmijNrecKqZce6gQWdoFTZVlJaylRD25vlRCwg42FwYXdSPn3xXUaOYUZgYY3j_lqmvcEX1Eq8bXxqRBKMJaEvWrOW8zlrKecvT65nzWXpWxxXZxxSfnb5oxyITjB_Lz5NUe3IenRxzVa6H2ZAqCbAHbMyW5g560OaPVYRtghlzJaRrTy44R0HND9FEZvNzpGCGiZ4mwFB0f_AGgFsVTGd80bp0OBy6fzovl5e_Nj8W129_3rcjG_m1nGu3FmGNBWssEC71pCLO4Gw4zj1FHGHG95r3uQGgvSM9GZlnW6t1h0LTOSV6EXzfLIOyS9Vfvsdzo_qqS9-mtIea10rrEGUC0bzCC7rncgGTiqiXBGt1Izg4WWpnJ9OXLtJ7ODGlMcsw4vSF--RL9R6_SgCO5xx3tZGT49MeT0e4Iyqp0vFkLQEdJUVCsE7QSrWqEf_4Nu05RjrdUB1VYlglTU1RG11jUDH12qH9u6h0ODUgTnq33OOZGkyqEen48ONqdSMrjn8AlWh7lRp3NT4R9OU34G_5sS-gc3E703</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2882288181</pqid></control><display><type>article</type><title>A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing</title><source>PubMed (Medline)</source><source>Publicly Available Content (ProQuest)</source><creator>Yang, Jie ; Ding, Ao ; Zhou, Jia-Le ; Yan, Bing-Yong ; Gu, Zhen ; Wang, Hui-Feng</creator><creatorcontrib>Yang, Jie ; Ding, Ao ; Zhou, Jia-Le ; Yan, Bing-Yong ; Gu, Zhen ; Wang, Hui-Feng</creatorcontrib><description>Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K
, NH
, Na
, Ca
, and Mg
based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media.</description><identifier>ISSN: 2079-6374</identifier><identifier>EISSN: 2079-6374</identifier><identifier>DOI: 10.3390/bios13100914</identifier><identifier>PMID: 37887107</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bioreactors ; Biosensors ; Calcium ions ; Calibration ; capsule sensor ; Carbon dioxide ; Cell culture ; Cell Culture Techniques ; Cell growth ; Chemical indicators ; Chemical properties ; Chemical sensors ; Contamination ; Culture media ; Data transmission ; Design and construction ; Dissolved oxygen ; Electrochemical apparatus ; Electrochemistry ; Electrodes ; Identification and classification ; In situ measurement ; in situ monitoring ; Ion-Selective Electrodes ; Ions ; Magnesium ; Management ; Metabolism ; Metabolites ; multichannel ; Multichannel communication ; Optimization ; Self calibration ; Sensors ; Signal processing ; solid-contact ion-selective electrode ; wireless sensor network</subject><ispartof>Biosensors (Basel), 2023-10, Vol.13 (10), p.914</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c475t-b4e3294dce75211c05db4bf73f344f7276a6e9a0816485b245a6c08524b97b973</cites><orcidid>0000-0003-3913-3081</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2882288181/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2882288181?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37887107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Ding, Ao</creatorcontrib><creatorcontrib>Zhou, Jia-Le</creatorcontrib><creatorcontrib>Yan, Bing-Yong</creatorcontrib><creatorcontrib>Gu, Zhen</creatorcontrib><creatorcontrib>Wang, Hui-Feng</creatorcontrib><title>A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing</title><title>Biosensors (Basel)</title><addtitle>Biosensors (Basel)</addtitle><description>Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K
, NH
, Na
, Ca
, and Mg
based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media.</description><subject>Bioreactors</subject><subject>Biosensors</subject><subject>Calcium ions</subject><subject>Calibration</subject><subject>capsule sensor</subject><subject>Carbon dioxide</subject><subject>Cell culture</subject><subject>Cell Culture Techniques</subject><subject>Cell growth</subject><subject>Chemical indicators</subject><subject>Chemical properties</subject><subject>Chemical sensors</subject><subject>Contamination</subject><subject>Culture media</subject><subject>Data transmission</subject><subject>Design and construction</subject><subject>Dissolved oxygen</subject><subject>Electrochemical apparatus</subject><subject>Electrochemistry</subject><subject>Electrodes</subject><subject>Identification and classification</subject><subject>In situ measurement</subject><subject>in situ monitoring</subject><subject>Ion-Selective Electrodes</subject><subject>Ions</subject><subject>Magnesium</subject><subject>Management</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>multichannel</subject><subject>Multichannel communication</subject><subject>Optimization</subject><subject>Self calibration</subject><subject>Sensors</subject><subject>Signal processing</subject><subject>solid-contact ion-selective electrode</subject><subject>wireless sensor network</subject><issn>2079-6374</issn><issn>2079-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdUk1vGyEQXVWtmijNrecKqZce6gQWdoFTZVlJaylRD25vlRCwg42FwYXdSPn3xXUaOYUZgYY3j_lqmvcEX1Eq8bXxqRBKMJaEvWrOW8zlrKecvT65nzWXpWxxXZxxSfnb5oxyITjB_Lz5NUe3IenRxzVa6H2ZAqCbAHbMyW5g560OaPVYRtghlzJaRrTy44R0HND9FEZvNzpGCGiZ4mwFB0f_AGgFsVTGd80bp0OBy6fzovl5e_Nj8W129_3rcjG_m1nGu3FmGNBWssEC71pCLO4Gw4zj1FHGHG95r3uQGgvSM9GZlnW6t1h0LTOSV6EXzfLIOyS9Vfvsdzo_qqS9-mtIea10rrEGUC0bzCC7rncgGTiqiXBGt1Izg4WWpnJ9OXLtJ7ODGlMcsw4vSF--RL9R6_SgCO5xx3tZGT49MeT0e4Iyqp0vFkLQEdJUVCsE7QSrWqEf_4Nu05RjrdUB1VYlglTU1RG11jUDH12qH9u6h0ODUgTnq33OOZGkyqEen48ONqdSMrjn8AlWh7lRp3NT4R9OU34G_5sS-gc3E703</recordid><startdate>20231005</startdate><enddate>20231005</enddate><creator>Yang, Jie</creator><creator>Ding, Ao</creator><creator>Zhou, Jia-Le</creator><creator>Yan, Bing-Yong</creator><creator>Gu, Zhen</creator><creator>Wang, Hui-Feng</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3913-3081</orcidid></search><sort><creationdate>20231005</creationdate><title>A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing</title><author>Yang, Jie ; Ding, Ao ; Zhou, Jia-Le ; Yan, Bing-Yong ; Gu, Zhen ; Wang, Hui-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-b4e3294dce75211c05db4bf73f344f7276a6e9a0816485b245a6c08524b97b973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bioreactors</topic><topic>Biosensors</topic><topic>Calcium ions</topic><topic>Calibration</topic><topic>capsule sensor</topic><topic>Carbon dioxide</topic><topic>Cell culture</topic><topic>Cell Culture Techniques</topic><topic>Cell growth</topic><topic>Chemical indicators</topic><topic>Chemical properties</topic><topic>Chemical sensors</topic><topic>Contamination</topic><topic>Culture media</topic><topic>Data transmission</topic><topic>Design and construction</topic><topic>Dissolved oxygen</topic><topic>Electrochemical apparatus</topic><topic>Electrochemistry</topic><topic>Electrodes</topic><topic>Identification and classification</topic><topic>In situ measurement</topic><topic>in situ monitoring</topic><topic>Ion-Selective Electrodes</topic><topic>Ions</topic><topic>Magnesium</topic><topic>Management</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>multichannel</topic><topic>Multichannel communication</topic><topic>Optimization</topic><topic>Self calibration</topic><topic>Sensors</topic><topic>Signal processing</topic><topic>solid-contact ion-selective electrode</topic><topic>wireless sensor network</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Jie</creatorcontrib><creatorcontrib>Ding, Ao</creatorcontrib><creatorcontrib>Zhou, Jia-Le</creatorcontrib><creatorcontrib>Yan, Bing-Yong</creatorcontrib><creatorcontrib>Gu, Zhen</creatorcontrib><creatorcontrib>Wang, Hui-Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biosensors (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Jie</au><au>Ding, Ao</au><au>Zhou, Jia-Le</au><au>Yan, Bing-Yong</au><au>Gu, Zhen</au><au>Wang, Hui-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing</atitle><jtitle>Biosensors (Basel)</jtitle><addtitle>Biosensors (Basel)</addtitle><date>2023-10-05</date><risdate>2023</risdate><volume>13</volume><issue>10</issue><spage>914</spage><pages>914-</pages><issn>2079-6374</issn><eissn>2079-6374</eissn><abstract>Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K
, NH
, Na
, Ca
, and Mg
based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37887107</pmid><doi>10.3390/bios13100914</doi><orcidid>https://orcid.org/0000-0003-3913-3081</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2079-6374 |
| ispartof | Biosensors (Basel), 2023-10, Vol.13 (10), p.914 |
| issn | 2079-6374 2079-6374 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_24dbd9556fe94ef3a18fba29a4b08a9b |
| source | PubMed (Medline); Publicly Available Content (ProQuest) |
| subjects | Bioreactors Biosensors Calcium ions Calibration capsule sensor Carbon dioxide Cell culture Cell Culture Techniques Cell growth Chemical indicators Chemical properties Chemical sensors Contamination Culture media Data transmission Design and construction Dissolved oxygen Electrochemical apparatus Electrochemistry Electrodes Identification and classification In situ measurement in situ monitoring Ion-Selective Electrodes Ions Magnesium Management Metabolism Metabolites multichannel Multichannel communication Optimization Self calibration Sensors Signal processing solid-contact ion-selective electrode wireless sensor network |
| title | A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A47%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Floating%20Capsule%20Electrochemical%20System%20for%20In%20Situ%20and%20Multichannel%20Ion-Selective%20Sensing&rft.jtitle=Biosensors%20(Basel)&rft.au=Yang,%20Jie&rft.date=2023-10-05&rft.volume=13&rft.issue=10&rft.spage=914&rft.pages=914-&rft.issn=2079-6374&rft.eissn=2079-6374&rft_id=info:doi/10.3390/bios13100914&rft_dat=%3Cgale_doaj_%3EA771911917%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c475t-b4e3294dce75211c05db4bf73f344f7276a6e9a0816485b245a6c08524b97b973%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2882288181&rft_id=info:pmid/37887107&rft_galeid=A771911917&rfr_iscdi=true |