A Simple Measure to Assess Hyperinflation and Air Trapping: 1-Forced Expiratory Volume in Three Second / Forced Vital Capacity

• Published in: Balkan medical journal 2017-03, Vol.34 (2), p.113-118
• Main Authors: Börekçi, Sermin, Demir, Tunçalp, Görek Dilektaşlı, Aslı, Uygun, Melahat, Yıldırım, Nurhayat
• Format: Article
• Language: English
• Subjects: 1-FEV3/FVC; 12.95; Adult; Aged; Analysis; and total lung capacity (r=0.47; p<0.0001). 1-FEV3/FVC was negatively correlated with forced expiratory flow25-75 (r=−0.84; p<0.0001). The upper limit of 95% confidence interval for 1-FEV3/FVC was 13.7%. 1-FEV3/FVC showed significant correlations with parameters of air trapping and hyperinflation measured by whole-body plethysmography. Importantly; Cross-Sectional Studies; Female; Forced Expiratory Volume - physiology; functional residual capacity-pleth (r=0.61; p<0.0001); Humans; hyperinflation; Lung - physiopathology; Lung volume measurements; Lung Volume Measurements - methods; Male; Middle Aged; Original; respectively. The mean 1-FEV3/FVC was 4.9% in the FEV1/FVC ≥70% group (n=644) vs. 24.1% in the FEV1/FVC <70% group (n=466). A positive correlation was found between 1-FEV3/FVC and residual volume (r=0.70; p<0.0001); Respiratory Function Tests - methods; Retrospective Studies; Severity of Illness Index; Spirometry; Spirometry - methods; Statistics, Nonparametric; these correlations were higher in study participants with FEV1/FVC <70% or FEV3/FVC < LLN compared to those with FEV1/FVC ≥70% or FEV3/FVC ≥ LLN; Tıp; Vital Capacity - physiology; Weights and Measures - standards; with a mean age of 52.5±15.6 years. Mean FEV3/FVC and 1-FEV3/FVC were 87.05
• ISSN: 2146-3123; 2146-3131
• DOI: 10.4274/balkanmedj.2015.0857

Several recent studies have suggested that 1 minus-forced expiratory volume expired in 3 seconds / forced vital capacity (1-FEV3/FVC) may be an indicator of distal airway obstruction and a promising measure to evaluate small airways dysfunction. To investigate the associations of 1-FEV3/FVC with the spirometric measures and lung volumes that assess small airways dysfunction and reflects hyperinflation and air trapping. Retrospective cross-sectional study. Retrospective assessment of a total of 1110 cases who underwent body plethysmographic lung volume estimations between a time span from 2005 to 2012. Patients were assigned into two groups: firstly by FEV1/FVC (FEV1/FVC