Family cancer history and smoking habit associated with sarcoma in a Japanese population study

Sarcoma is a rare cancer, and little is known about the etiology, lifestyle epidemiology, and actual circumstances of treatment in hospitals in Japan. Understanding these issues is essential for the effective prevention and treatment of sarcoma. We therefore investigated the incidence of a personal...

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Bibliographic Details
Published in:Scientific reports 2022-10, Vol.12 (1), p.17129-17129, Article 17129
Main Authors: Araki, Yoshihiro, Yamamoto, Norio, Tanzawa, Yoshikazu, Higashi, Takahiro, Kuchiba, Aya, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Igarashi, Kentaro, Endo, Makoto, Kobayashi, Eisuke, Tsuchiya, Hiroyuki, Kawai, Akira
Format: Article
Language:English
Subjects:
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692/4028
692/499
692/700
Cancer
Diabetes mellitus
Dyslipidemia
Epidemiology
Etiology
Histiocytoma, Malignant Fibrous
Histology
Humanities and Social Sciences
Humans
Hypertension
Japan - epidemiology
Liposarcoma
multidisciplinary
Nutrition Surveys
Patients
Peripheral nerves
Population studies
Sarcoma
Sarcoma - epidemiology
Sarcoma - etiology
Sarcoma - pathology
Science
Science (multidisciplinary)
Smoking
Smoking - adverse effects
Soft Tissue Neoplasms - pathology
Soft tissue sarcoma
Tumors
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Summary:Sarcoma is a rare cancer, and little is known about the etiology, lifestyle epidemiology, and actual circumstances of treatment in hospitals in Japan. Understanding these issues is essential for the effective prevention and treatment of sarcoma. We therefore investigated the incidence of a personal and family cancer history in a total of 1320 sarcoma patients at the National Cancer Center Hospital. In addition, obesity, hypertension, dyslipidemia, diabetes mellitus, drinking, smoking, age and sex were compared in a descriptive study of 1159 of these sarcoma patients who were ≥ 20 years of age, and 7738 controls derived from the National Health and Nutrition Examination Survey in Japan. A total of 8% of sarcoma patients had a personal history of another cancer, and 30% of soft tissue sarcoma patients had a family cancer history in a first-degree relative (malignant peripheral nerve sheath tumor, 52%; leiomyosarcoma, 46%). A smoking habit was associated with the development of sarcoma (odds ratio [OR], 2.05; 95% confidence interval, 1.78–2.37; p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-21500-0