Radiological lymph‐node size improves the prognostic value of systemic inflammation index in rectal cancer with pathologically negative nodes

• Published in: Cancer medicine (Malden, MA) MA), 2023-05, Vol.12 (9), p.10303-10314
• Main Authors: Peng, Shaoyong, Liu, Xiaoxia, Li, Yingjie, Yu, Huichuan, Xie, Yumo, Wang, Xiaolin, Zhou, Jiaming, Zhu, Mingxuan, Luo, Yanxin, Huang, Meijin
• Format: Article
• Language: English
• Subjects: Archives & records; Cancer; Colonoscopy; Colorectal cancer; Humans; Inflammation; Inflammation - pathology; Leukocytes (neutrophilic); Lymph nodes; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic system; Lymphocytes; Metastasis; Multivariate analysis; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Neutrophils; NLR; node‐negative rectal cancer; Patients; Prognosis; radiological lymph node; Rectal Neoplasms - pathology; Rectum; Retrospective Studies; Risk factors; Surgery; survival outcome
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.5761

Background The relationship between the radiological lymph node (rLN) size and survival outcome in node‐negative rectal cancer is still uncertain. In this study, we aimed to explore the role of enlarged rLN in predicting the survival of node‐negative rectal cancers. Methods We retrospectively reviewed the records of 722 node‐negative rectal cancer who underwent curative resection. Factors associated with DFS (disease‐free survival) and CSS (cancer‐specific survival) were assessed with univariate and multivariate analysis. Survival analysis was performed according to presence with or without enlarged rLN. Combining rLN with NLR as a new index‐inflammation immune score (IIS) for predicting survival. Comparing different models to assess the predictive powers. Results A total of 119 patients had tumor recurrence and 73 patients died due to cancer. Patients with enlarged rLN (≥5 mm) was significantly associated with better DFS (HR:0.517, 95%CI:0.339–0.787, p = 0.002) and CSS (HR:0.43, 95%CI:0.242–0.763, p = 0.004). The risk factors of recurrence were rLN, neutrophil‐lymphocyte ratio (NLR), CEA level, and distance from the anal verge. The risk of recurrence increased by 1.88‐ and 2.83‐fold for the high score in IIS compared with the low and intermediate score group (All p