Differences in subthalamic oscillatory activity in the two hemispheres associated with severity of Parkinson’s disease

Background: It is well known that motor features of Parkinson’s disease (PD) commonly begin on one side of the body and extend to the other side with disease progression. The onset side generally remains more severely affected over the course of the disease. However, the pathophysiology underlying t...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in aging neuroscience 2023-08, Vol.15, p.1185348
Main Authors: Zhao, Xuemin, Zhuang, Ping, Hallett, Mark, Zhang, Yuqing, Li, Jianyu, Wen, Yi, Li, Jiping, Wang, Yunpeng, Hu, Yongsheng, Li, Yongjie
Format: Article
Language:English
Subjects:
asymmetry
Deep brain stimulation
Electrical stimuli
Electrodes
Firing rate
Hemispheric laterality
microelectrode recording
Movement disorders
Neurodegenerative diseases
Neurons
Neuroscience
oscillation
Parkinson's disease
Pathophysiology
Software
Solitary tract nucleus
Subthalamic nucleus
Surgery
Tremor
Tremor (Muscular contraction)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: It is well known that motor features of Parkinson’s disease (PD) commonly begin on one side of the body and extend to the other side with disease progression. The onset side generally remains more severely affected over the course of the disease. However, the pathophysiology underlying the asymmetry of motor manifestations remains unclear. The purpose of the present study is to examine whether alterations in neuronal activity in the subthalamic nucleus (STN) associate with PD severity. Methods: Microelectrode recording was performed in the STN during targeting for 30 patients in the treatment of deep brain stimulation. The mean spontaneous firing rate (MSFR), power density spectral analysis, and correlations were calculated. Characteristics of subthalamic oscillatory activity were compared between two hemispheres. UPDRS III scores during “Off” and “On” states were obtained for the body side of initial symptoms (BSIS) and the body side of extended symptoms (BSES). Results: There were significant differences of MSFR (41.3 ± 11.0 Hz vs 35.2 ± 10.0 Hz,) and percentage of ß frequency oscillatory neurons (51.3% vs 34.9%) between BSIS and BSES. The percentage of ß frequency oscillatory neurons correlated with the bradykinesia/rigidity scores for both sides (p
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1185348