Emerging roles of circular RNAs in tuberculosis

Tuberculosis (TB) remains a major global health issue, resulting in around 1.5 million people deaths each year. Better diagnostic and therapeutic tools are urgently needed. Circular RNAs (circRNAs) are a new class of noncoding RNAs with a covalently closed structure, and exhibit a tissue-, cell-, an...

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Bibliographic Details
Published in:Frontiers in immunology 2022-09, Vol.13, p.995701-995701
Main Authors: Wang, Qinglan, Yang, Danni, Zuo, Yinan, Wang, Dan, Li, Weimin
Format: Article
Language:English
Subjects:
biomarker
circRNA
circular RNA
immune response
Immunology
mycobacterium tuberculosis
tuberculosis
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Summary:Tuberculosis (TB) remains a major global health issue, resulting in around 1.5 million people deaths each year. Better diagnostic and therapeutic tools are urgently needed. Circular RNAs (circRNAs) are a new class of noncoding RNAs with a covalently closed structure, and exhibit a tissue-, cell-, and developmental stage-specific expression pattern. Recently, circRNAs were thought to be regulatory molecules implicated in the onset and progression of a series of human diseases including tuberculosis. In tuberculosis, circRNAs have been shown to regulate host anti-TB immune responses, such as decreasing monocyte apoptosis, enhancing autophagy and promoting macrophage polarization. Importantly, circRNAs are physically stable and abundant in several types of body fluids. Therefore they are considered as promising minimally-invasive biomarkers. In this review, we focus on the recent advances in the immune regulatory roles of circRNAs, as well as their potential diagnostic value in TB.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.995701