Prognostic Value of Gai＇s Plaque Score and Agatston Coronary Artery Calcium Score for Functionally Significant Coronary Artery Stenosis

• Published in: Chinese medical journal 2016-12, Vol.129 (23), p.2792-2796
• Main Authors: Zhang, Chuang, Yang, Shuang, Gai, Lu-Yue, Han, Zhi-Qi, Xin, Qian, Yang, Xiao-Bo, Yang, Jun-Jie, Jin, Qin-Hua
• Format: Article
• Language: English
• Subjects: Computed Tomography Coronary Angiography; Coronary Calcification; Coronary Stenosis; Fractional Flow Reserve; 价值; 冠状动脉造影; 动脉狭窄; 斑块; 积分; 血流动力学; 钙化; 预后
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.194636

Background： The prognostic valtles of the coronary computed tornography angiography （CCTA） score for predicting future cardiovascular events have been previously demonstrated in numerous studies. However, few studies have used the rich information available from CCTA to detect functionally significant coronary lesions. We sought to compare the prognostic values of Gai＇s plaque score and the coronary artery calcium score tCACS） of CCTA for predicting functionally significant coronary lesions, using fractional flow reserve （FFR） as the gold standard. Methods： We retrospectively analyzed 107 visually assessed significant coronary lesions in 88 patients （mean age, 59.6 ± 10.2 years： 76.14% of males） wino underwent CCTA, invasive coronary angiography, and invasive FFR nneasurement. An FFR 〈0.80 indicated hemodynamically significant coronary stenosis. Lesions were divided into two groups using an FFR cutoffvalue of 0.80. We compared Gai＇s plaque scores and CACS between the two groups and evaluated the correlations of these scores with FFR. The statistical methods included unpaired t-test, Mann-Whitney U-test, and Spearman＇s correlation coefficients. Results： Coronary lesions with FFR 〈0.80 lind Inigtner Gai＇s scores than those with FFR 〉0.80. Gai＇s score had the strongest correlation with FFR （r= 0.48, P 〈 0.01 ） and lind a greater area under tlne curve 0.72 （95% confidence interval： 0.61 0.82： P 〈 0.01 ） than the CACS of whole arteries and a single artery. Conelusions： Botin CACS in a single artery and Gai＇s plaque score demonstrated a good capacity to assess functionally significant coronary artery stenosis when compared to the gold standard FFR. However, Gai＇s plaque score was more predictive of FFR 〈0.80. Gai＇s score cain be easily calculated in daily clinical practice and could be used when considering revascularization.