Design, development and optimization of selfmicroemulsifying drug delivery system of an anti-obesity drug

The aim of the present work was to formulate a self-microemulsifying drug delivery system (SMEDDS) containing orlistat. The oil, surfactant and co-surfactant were decided based on the solubility studies. Pseudoternary phase diagrams were plotted, microemulsification area was determined and different...

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Bibliographic Details
Published in:Journal of pharmacy & bioallied science 2012-03, Vol.4 (5), p.21-22
Main Authors: Desai, Jagruti, Khatri, Nirav, Chauhan, Sachin, Seth, Avinash
Format: Article
Language:English
Subjects:
Bioavailability
Dissolution
Drug delivery systems
Drugs
Health aspects
Obesity
Optimization
Orlistat
phase diagram
Studies
thermodynamic stability
Vehicles
Weight reducing preparations
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Summary:The aim of the present work was to formulate a self-microemulsifying drug delivery system (SMEDDS) containing orlistat. The oil, surfactant and co-surfactant were decided based on the solubility studies. Pseudoternary phase diagrams were plotted, microemulsification area was determined and different formulations were prepared. Particle size, zeta potential, dispersibility test and thermodynamic stability studies were measured. In-vitro dissolution test of thermodynamically stable formulations OS-B and OS-C were carried and results were compared with those of plain drug and suspension formulation. Stability studies performed indicated that formulation OS-C remained stable over 12 months period. Thus this investigation concluded that hydrophobic drugs like orlistat can be delivered effectively through the formulation of SMEDDS.
ISSN:0975-7406
0976-4879
0975-7406
0976-4879
DOI:10.4103/0975-7406.94124