Reno-protective effect of garlic extract against immobilization stress induced changes in rats

Objective: To examine immobilization stress-induced antioxidant defense alterations in rat kidney and the antioxidant effects of aqueous garlic extract in pre and post stress extract treatments. Methods: Albino rats were treated with aqueous extract of garlic both before and 6 h of immobilization st...

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Bibliographic Details
Published in:Asian Pacific journal of tropical biomedicine 2015-05, Vol.5 (5), p.364-369
Main Authors: Zaidi, Syed Kashif, Ansari, Shakeel Ahmed, Ashraf, Ghulam Md, Jafri, Mohammad Alam, Tabrez, Shams, Banu, Naheed
Format: Article
Language:English
Subjects:
Allium sativum
ALT
Antioxidant
Antioxidant enzymes
AST
enzymes
Garlic
MDA
Stress
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Summary:Objective: To examine immobilization stress-induced antioxidant defense alterations in rat kidney and the antioxidant effects of aqueous garlic extract in pre and post stress extract treatments. Methods: Albino rats were treated with aqueous extract of garlic both before and 6 h of immobilization stress. Pro-oxidant eminence of rat kidney was assessed by determining the levels of glutathione, thiobarbituric acid reactive substances, aspartate aminotransferase, alanine aminotransferase, glucose, uric acid, alkaline phosphatase and antioxidant enzymes activities. Results: In response to 6 h of immobilization stress, a significant rise in the level of kidney enzymes was recorded. However, antioxidant enzyme activities showed a sharp decline. Conclusions: The extract treatment before and after the stress reverted the activities of above mentioned enzymes towards their control values. Hence, garlic extract can be given as nutritional supplement for scavenging the free radicals generated in rat kidney.
ISSN:2221-1691
2588-9222
DOI:10.1016/S2221-1691(15)30370-1