Exploring the Inter- and Intra-Specific Variability of Androctonus Scorpion Venoms

Scorpion venom possesses a lethal sting and potential medicinal properties, making it a captivating natural elixir. Our study aimed to unravel the composition of Androctonus scorpionvenoms in Morocco. Using electrospray mass spectrometry and high-performance liquid chromatography (HPLC), we conducte...

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Bibliographic Details
Published in:Biology and life sciences forum 2023-07, Vol.24 (1), p.12
Main Authors: Ines Hilal, Soukaina Khourcha, Amal Safi, Abdelaziz Hmyene, Reto Stöcklin, Naoual Oukkache
Format: Article
Language:English
Subjects:
Androctonus
LC-MS
peptides
peptidic maps
scorpion
venom
Online Access:Get full text
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Summary:Scorpion venom possesses a lethal sting and potential medicinal properties, making it a captivating natural elixir. Our study aimed to unravel the composition of Androctonus scorpionvenoms in Morocco. Using electrospray mass spectrometry and high-performance liquid chromatography (HPLC), we conducted a thorough analysis to gain detailed insights into venom composition. The data unveiled a wide range of molecular weights, influenced by factors such as species, genus, location, age, sex, and diet. Short toxins (2000–4000 Da) predominated in the venoms, effectively blocking K+ channels, while larger molecular weights (>4000 Da) corresponded to long toxins that modulate Na+ channels. Furthermore, we made intriguing discoveries of previously unidentified peptides (
ISSN:2673-9976
DOI:10.3390/IECT2023-14797