Generation of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism

Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and is characterized by progressive degeneration of the macula, the central region of the retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cel...

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Bibliographic Details
Published in:Stem cell research 2019-07, Vol.38, p.101473-101473, Article 101473
Main Authors: Garcia-Delgado, Ana B., Calado, Sofia M., Valdes-Sanchez, Lourdes M., Montero-Sanchez, Adoracion, Ponte-Zuñiga, Beatriz, de la Cerda, Berta, Bhattacharya, Shom Shanker, Diaz-Corrales, Francisco J.
Format: Article
Language:English
Subjects:
Aged, 80 and over
Cell Line
Cellular Reprogramming Techniques
Complement Factor H - genetics
Complement Factor H - metabolism
Female
Humans
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - pathology
Macular Degeneration - genetics
Macular Degeneration - metabolism
Macular Degeneration - pathology
Polymorphism, Genetic
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Summary:Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and is characterized by progressive degeneration of the macula, the central region of the retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) from a patient with a clinical diagnosis of dry AMD carrying the CFH Y402H polymorphism. Sendai virus was using for reprogramming and the pluripotent and differentiation capacity of the cells were assessed by immunocytochemistry and RT-PCR.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2019.101473