Long noncoding RNA MYOSLID promotes invasion and metastasis by modulating the partial epithelial-mesenchymal transition program in head and neck squamous cell carcinoma

• Published in: Journal of experimental & clinical cancer research 2019-06, Vol.38 (1), p.278-278, Article 278
• Main Authors: Xiong, Hong-Gang, Li, Hao, Xiao, Yao, Yang, Qi-Chao, Yang, Lei-Lei, Chen, Lei, Bu, Lin-Lin, Zhang, Wen-Feng, Zhang, Jia-Li, Sun, Zhi-Jun
• Format: Article
• Language: English
• Subjects: Antisense RNA; Biological markers; Cadherins - metabolism; Cancer; Cancer genetics; Cancer metastasis; Carcinoma; Care and treatment; Cell Adhesion Molecules - metabolism; Cell Line, Tumor; Cell Movement - genetics; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; Genes; Genetic aspects; Genetic research; Genomes; Genomics; Head and neck cancer; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Humans; Immunohistochemistry; Kalinin; Keratinocytes; Laminin; Long non-coding RNA; Male; Membrane Glycoproteins - metabolism; Messenger RNA; Middle Aged; MYOSLID; Neoplasm Invasiveness; Partial epithelial to mesenchymal transition; Prognosis; Prognostic biomarkers; Regression analysis; RNA; RNA, Long Noncoding - metabolism; Snail Family Transcription Factors - metabolism; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - mortality; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - secondary; Stem cells; Vimentin - metabolism; Wound care; Wound healing
• ISSN: 1756-9966; 0392-9078; 1756-9966
• DOI: 10.1186/s13046-019-1254-4

Partial epithelial mesenchymal transition (p-EMT) was found to play a potential role in the initial stage of metastasis in human head and neck squamous cell carcinoma (HNSCC). Some long noncoding RNAs (lncRNAs) have been reported to function as promoters or inhibitors of cancer metastasis. This study aimed to identify p-EMT-related lncRNAs in HNSCC. Differentially expressed lncRNAs (DE-lncRNAs) and mRNAs (DEGs) in HNSCC obtained from The Cancer Genome Atlas (TCGA) were screened out by using the "edgeR" package. DE-lncRNAs in the Oral squamous cell carcinoma (OSCC) lncRNA microarray dataset GSE84805 were screened out by using the "limma" package. Slug-related lncRNAs were determined by Pearson correlation analysis (|Pearson correlation coefficient| ≥ 0.4, p