Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective

Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling of immunosuppressive metabolites. Tumor cells and immunosuppressive cells outcompete immune effector cells for essential nutrients. Meanw...

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Published in:EBioMedicine 2024-09, Vol.107, p.105301, Article 105301
Main Authors: Liu, Jieyu, Bai, Yinan, Li, Yinggang, Li, Xiaoling, Luo, Kui
Format: Article
Language:English
Subjects:
Anti-tumor immunity
Immunometabolism
Metabolic reprogramming
Nanomedicine
Review
Tumor immune microenvironment
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Li, Yinggang
Li, Xiaoling
Luo, Kui
description Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling of immunosuppressive metabolites. Tumor cells and immunosuppressive cells outcompete immune effector cells for essential nutrients. Meanwhile, a wide range of tumor cell-derived toxic metabolites exerts negative impacts on anti-tumor immune response, diminishing the efficacy of immunotherapy. Nanomedicine with excellent targetability offers a novel approach to improving cancer immunotherapy via metabolically reprogramming the immunosuppressive TME. Herein, we review recent strategies of enhancing immunotherapeutic effects through rewiring tumor metabolism via nanomedicine. Attention is drawn on immunometabolic tactics for immune cells and stromal cells in the TME via nanomedicine. Additionally, we discuss future directions of developing metabolism-regulating nanomedicine for precise and efficacious cancer immunotherapy.
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subjects Anti-tumor immunity
Immunometabolism
Metabolic reprogramming
Nanomedicine
Review
Tumor immune microenvironment
title Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective
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