Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes

• Published in: Pharmaceutics 2022-07, Vol.14 (8), p.1594
• Main Authors: Navarro, Juan A, Decara, Juan, Medina-Vera, Dina, Tovar, Ruben, Lopez-Gambero, Antonio J, Suarez, Juan, Pavón, Francisco Javier, Serrano, Antonia, de Ceglia, Marialuisa, Sanjuan, Carlos, Baltasar, Yolanda Alfonso, Baixeras, Elena, Rodríguez de Fonseca, Fernando
• Format: Article
• Language: English
• Subjects: Carbohydrates; Carob; carob fruit; Chemical properties; Chromatography; D-Pinitol; Diabetes; Diabetics; Epidemics; Fatty acids; Food; Food and nutrition; Glucose; Health aspects; Health care; Homeostasis; Hormones; insulin; Insulin resistance; Laboratories; liver steatosis; Metabolism; Natural sweeteners; Obesity; Physiological aspects; Physiology; Plasma; Polyols; Pregnancy; sweeteners; Syrups; Testing
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics14081594

The widespread use of added sugars or non-nutritive sweeteners in processed foods is a challenge for addressing the therapeutics of obesity and diabetes. Both types of sweeteners generate health problems, and both are being blamed for multiple complications associated with these prevalent diseases. As an example, fructose is proven to contribute to obesity and liver steatosis, while non-nutritive sweeteners generate gut dysbiosis that complicates the metabolic control exerted by the liver. The present work explores an alternative approach for sweetening through the use of a simple carob-pod-derived syrup. This sweetener consists of a balanced mixture of fructose (47%) and glucose (45%), as sweetening sugars, and a functional natural ingredient (D-Pinitol) at a concentration (3%) capable of producing active metabolic effects. The administration of this syrup to healthy volunteers (50 g of total carbohydrates) resulted in less persistent glucose excursions, a lower insulin response to the hyperglycemia produced by its ingestion, and an enhanced glucagon/insulin ratio, compared to that observed after the ingestion of 50 g of glucose. Daily administration of the syrup to Wistar rats for 10 days lowered fat depots in the liver, reduced liver glycogen, promoted fat oxidation, and was devoid of toxic effects. In addition, this repeated administration of the syrup improved glucose handling after a glucose (2 g/kg) load. Overall, this alternative functional sweetener retains the natural palatability of a glucose/fructose syrup while displaying beneficial metabolic effects that might serve to protect against the progression towards complicated obesity, especially the development of liver steatosis.