Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years

• Published in: BMC geriatrics 2020-03, Vol.20 (1), p.111-111, Article 111
• Main Authors: Son, Ki Young, Shin, Dong Wook, Lee, Ji Eun, Kim, Sang Hyuck, Yun, Jae Moon, Cho, Belong
• Format: Article
• Language: English
• Subjects: Adults; Body mass index; Cardiovascular disease; Cardiovascular diseases; Chronic illnesses; Cognition & reasoning; Cognitive ability; Demographic aspects; Diabetes; Diseases; Elderly; Geriatrics; Health insurance; Health risk assessment; Hypertension; Insurance; Kidney diseases; Longitudinal studies; Medical aid; Medical examination; Medical screening; Medical tests; Mobility; Mortality; Musculoskeletal tests; National health insurance; Obesity; Older people; Patient outcomes; Physically disabled persons; Physicians; Questionnaires; Risk factors; Smoking; Sociodemographics; South Korea; Statistics; Survival analysis; Time; Timed up and go test; Walking
• ISSN: 1471-2318; 1471-2318
• DOI: 10.1186/s12877-020-01509-8

The timed up and go test (TUG) is one of the most widely used tests of mobility. We aimed to examine whether the TUG is associated with cardiovascular (CV) events, CV mortality, and all-cause mortality. Subjects in the senior cohort database of the Korean National Health Insurance Service (2002-2013) who completed the TUG as part of the National Screening Program for Transitional Ages (NSPTA) during 2007-2008 were identified. An abnormal TUG result was defined as a time ≥ 10 s. Cox proportional hazard models were used to assess the associations between TUG results and CV events, CV mortality, and all-cause mortality. The mean follow-up period was 5.7 years. Incidence rates of CV events in the normal and abnormal TUG groups were 7.93 and 8.98 per 1000 person-years, while CV mortality rates were 0.96 and 1.51 per 1000 person-years, respectively. In a fully adjusted model, we found that abnormal TUG results were not associated with the incidences of CV events and CV mortality. However, abnormal TUG results (≥10 s) resulted in a 2.9-fold increase in CV mortality in women (adjusted hazard ratio 2.90, 95% confidence interval 1.15-7.30). Further, participants lacking certain CV risk factors, such as current cigarette smoking, obesity, or diabetes, had a higher CV mortality rate when TUG results were abnormal. Abnormal TUG results in subjects aged 66 years were associated with future CV mortality in women and in subjects without obesity, diabetes, or cigarette smoking. In patient with mobility impairment, physicians should consider CV disease risk, especially in women.