High‐Fat‐Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders

• Published in: Journal of the American Heart Association 2016-06, Vol.5 (6), p.n/a
• Main Authors: Lin, Bowen, Hasegawa, Yu, Takane, Koki, Koibuchi, Nobutaka, Cao, Cheng, Kim‐Mitsuyama, Shokei
• Format: Article
• Language: English
• Subjects: Adipose Tissue - pathology; Alzheimer Disease - etiology; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Amyloid - metabolism; Animals; Blood Glucose - metabolism; Blood Pressure - physiology; Body Weight - physiology; brain; Brain - pathology; Brain-Derived Neurotrophic Factor - metabolism; Catalase - metabolism; Cerebral Amyloid Angiopathy - etiology; Cerebral Amyloid Angiopathy - pathology; Cerebral Amyloid Angiopathy - physiopathology; cerebrovascular disorders; Cerebrovascular Disorders - etiology; Cerebrovascular Disorders - pathology; Cerebrovascular Disorders - physiopathology; Cognitive Dysfunction - etiology; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; Cyclooxygenase 2 - metabolism; Diet, High-Fat - adverse effects; Drinking - physiology; Eating - physiology; Glucose Tolerance Test; Male; Maze Learning; Mice, Inbred Strains; NADPH Oxidases - metabolism; nutrition; obesity; Occludin - metabolism; Organ Size - physiology; Original Research; Oxidative Stress - physiology; Superoxide Dismutase - metabolism; Urine - physiology
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.115.003154

Background The high‐fat Western diet is postulated to be associated with the onset and progression of Alzheimer's disease (AD). However, the role of high‐fat‐diet consumption in AD pathology is unknown. This study was undertaken to examine the role of high‐fat‐diet intake in AD. Methods and Results 5XFAD mice, a useful mouse model of AD, and control wild‐type mice were fed (1) high‐fat diet or (2) control diet for 10 weeks. The effects on cerebral AD pathology, cognitive function, and metabolic parameters were compared between each group of mice. High‐fat diet significantly enhanced cerebrovascular β‐amyloid (Aβ) deposition (P