Infection with multidrug-resistant gram-negative bacteria in a pediatric oncology intensive care unit: risk factors and outcomes

• Published in: Jornal de pediatria 2015-09, Vol.91 (5), p.435-441
• Main Authors: de Oliveira Costa, Patrícia, Atta, Elias Hallack, da Silva, André Ricardo Araújo
• Format: Article
• Language: English
• Subjects: Acinetobacter baumannii - isolation & purification; Acinetobacter Infections - microbiology; Adolescent; Anti-Bacterial Agents - therapeutic use; Bactérias gram-negativas multirresistentes; Cancer; Case-Control Studies; Child; Child, Preschool; Cross Infection - drug therapy; Cross Infection - microbiology; Cross Infection - mortality; Câncer; Drug Resistance, Multiple, Bacterial - drug effects; Fator de risco; Female; Gram-Negative Bacterial Infections - drug therapy; Gram-Negative Bacterial Infections - microbiology; Gram-Negative Bacterial Infections - mortality; Hematologic Neoplasms - drug therapy; Hematologic Neoplasms - microbiology; Hematologic Neoplasms - mortality; Humans; Infant; Infant, Newborn; Infection; Infecção; Intensive Care Units, Pediatric - statistics & numerical data; Length of Stay - statistics & numerical data; Male; Multidrug-resistant gram-negative; Outcome; Pediatric intensive care unit; PEDIATRICS; Pseudomonas aeruginosa - isolation & purification; Pseudomonas Infections - microbiology; Resultado; Risk factor; Risk Factors; Treatment Outcome; Unidade de terapia intensiva pediátrica
• ISSN: 0021-7557; 1678-4782; 1678-4782
• DOI: 10.1016/j.jped.2014.11.009

This study aimed at evaluating the predictors and outcomes associated with multidrug-resistant gram-negative bacterial (MDR-GNB) infections in an oncology pediatric intensive care unit (PICU). Data were collected relating to all episodes of GNB infection that occurred in a PICU between January of 2009 and December of 2012. GNB infections were divided into two groups for comparison: (1) infections attributed to MDR-GNB and (2) infections attributed to non-MDR-GNB. Variables of interest included age, gender, presence of solid tumor or hematologic disease, cancer status, central venous catheter use, previous Pseudomonas aeruginosa infection, healthcare-associated infection, neutropenia in the preceding 7 days, duration of neutropenia, length of hospital stay before ICU admission, length of ICU stay, and the use of any of the following in the previous 30 days: antimicrobial agents, corticosteroids, chemotherapy, or radiation therapy. Other variables included initial appropriate antimicrobial treatment, definitive inadequate antimicrobial treatment, duration of appropriate antibiotic use, time to initiate adequate antibiotic therapy, and the 7- and 30-day mortality. Multivariate logistic regression analyses showed significant relationships between MDR-GNB and hematologic diseases (odds ratio [OR] 5.262; 95% confidence interval [95% CI] 1.282–21.594; p=0.021) and healthcare-associated infection (OR 18.360; 95% CI 1.778–189.560; p=0.015). There were significant differences between MDR-GNB and non-MDR-GNB patients for the following variables: inadequate initial empirical antibiotic therapy, time to initiate adequate antibiotic treatment, and inappropriate antibiotic therapy. Hematologic malignancy and healthcare-associated infection were significantly associated with MDR-GNB infection in this sample of pediatric oncology patients. Este estudo visou avaliar os preditores e resultados associados às infecções por bactérias gram-negativas multirresistentes (BGN-MR) em uma unidade de terapia intensiva pediátrica oncológica (UTIP). Foram coletados dados com relação a todos os episódios de infecção por BGN que ocorreram em uma UTIP entre janeiro de 2009 e dezembro de 2012. As infecções por BGN foram divididas em dois grupos para comparação: 1) infecções atribuídas a BGN-MR e 2) infecções atribuídas a BGN não multirresistente. As variáveis de interesse incluíram idade, sexo, presença de tumor sólido ou malignidade hematológica, câncer, uso de cateter venoso central, infec