Exhaled breath diagnostics of lung and gastric cancers in China using nanosensors

• Published in: Cancer communications (London, England) England), 2020-06, Vol.40 (6), p.273-278
• Main Authors: Gharra, Alaa, Broza, Yoav Y., Yu, Guiping, Mao, Weidong, Shen, Dong, Deng, Lichun, Wu, Chun, Wang, Qiong, Sun, Xia, Huang, Jianming, Xuan, Zhuoqi, Huang, Bing, Wu, Song, Milyutin, Yana, Kloper‐Weidenfeld, Viki, Haick, Hossam
• Format: Article
• Language: English
• Subjects: Breath; Classification; Diagnosis; Gastric Cancer; Humidity; Letter to the Editor; Letters to the Editor; Lung Cancer; Nanoparticles; Reproducibility; Sensor; Sensors; VOCs; Volatile Organic Compound; Volatile organic compounds
• ISSN: 2523-3548; 2523-3548
• DOI: 10.1002/cac2.12030

List of Abbreviations VOC volatile organic compounds LC lung cancer GC gastric cancer GC-MS gas chromatography connected to mass spectrometry GNP gold-nanoparticles SiO2 silicon dioxide SU-8 photosensitive polymer TD thermal desorption DFA discriminant factor analysis TP true positive TN true negative FP false positive FN false negative ROC receiving operating characteristics AUC area under the curve Dear Editor, Breath analysis is a promising diagnostic approach for various conditions [ 1, 2]. Here, we carried out a VOC-based clinical trial for GC and LC detection in China to classify these two major malignancies with different genetic and cultural backgrounds, using our developed sensors [ 1] with newly-developed sensor-printing and sampling methods. TABLE 1 Main demographic and clinical characteristics of the study population Lung cancer patients † Gastric cancer patients † Characteristic Whole population Healthy volunteers Total Stage I Stage II Stage III Stage IV Unknown Total Stage I Stage II Stage III Stage IV Total (cases) 426 153 158 96 12 7 36 7 115 24 8 17 66 Age [years, median (range)] 60 (23-81) 47 (23-74) 67 (36-81) 62 (36-80) 67 (49-81) 65 (37-79) 67 (45-80) 67 (63-77) 67 (30-80) 65 (48-80) 66 (48-72) 69 (54-80) 67 (30-80) Gender [cases (%)] Male 261 (61) 107 (70) 76 (48) 32 (33) 6 (50) 6 (86) 28 (78) 4 (57) 78 (68) 18 (75) 4 (50) 11 (65) 45 (68) Female 165 (39) 46 (30) 82 (52) 64 (67) 6 (50) 1 (14) 8 (22) 3 (43) 37 (32) 6 (25) 4 (50) 6 (35) 21 (32) Smoking status [cases (%)] Yes 91 (21) 30 (20) 37 (23) 14 (15) 3 (27) 5 (71) 13 (36) 2 (29) 24 (21) 5 (21) 3 (38) 5 (29) 11 (17) No 335 (79) 123 (80) 121 (77) 82 (85) 9 (75) 2 (29) 23 (64) 5 (71) 91 (79) 19 (79) 5 (63) 12 (71) 55 (83) Alcohol use [cases (%)] Yes 99 (23.2) 37 (24) 40 (25.3) 13 (14) 3 (25) 5 (71) 15 (42) 4 (57) 22 (19) 4 (17) 2 (25) 2 (12) 14 (21) No 326 (76.5) 116 (76) 117 (74.1) 83 (86) 9 (75) 2 (29) 20 (56) 3 (43) 93 (81) 20 (83) 6 (75) 15 (88) 52 (79) Unknown 1 (0.2) 0 1 (0.6) 0 0 0 1 (3) 0 0 0 0 0 0 Asthma [cases (%)] Yes 3 (1) 3 (2) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) No 423 (99) 150 (98) 158 (100) 96 (100) 12 (100) 7 (100) 36 (100) 7 (100) 115 (100) 24 (100) 8 (100) 17 (100) 66 (100) H. pylori infection * [cases (%)] Yes 4 (1) - - - - - - - 4 (3) 1 (4) 1 (13) 0 (0) 2 (3) No 59 (14) - - - - - - - 59 (51) 9 (38) 3 (38) 10 (59) 37 (56) Unknown 52 (2) - - - - - - - 52 (45) 14 (58) 4 (50) 7 (41) 27 (41) Number of breath samples 545 153 222 136 16 7 5