CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion

CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with co...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2019-05, Vol.94 (3), p.341-343
Main Authors: Sandoval, Karina Romero, Machado, Maria Cecília Rivitti, de Oliveira, Zilda Najjar Prado, Nico, Marcello Menta Simonsen
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - drug therapy
Abnormalities, Multiple - genetics
Administration, Topical
Anticholesteremic Agents - administration & dosage
Case Report
Cholesterol
Cholesterol - biosynthesis
Cholesterol - metabolism
DERMATOLOGY
Female
Genetic Diseases, X-Linked - drug therapy
Genetic Diseases, X-Linked - genetics
Humans
Ichthyosiform Erythroderma, Congenital - drug therapy
Ichthyosiform Erythroderma, Congenital - genetics
Ichthyosis
Infant
Limb Deformities, Congenital - drug therapy
Limb Deformities, Congenital - genetics
Lovastatin
Lovastatin - administration & dosage
Metabolic Diseases - genetics
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Summary:CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with complete clearance of her CHILD nevus. The changes in skin lipid metabolism that explain the CHILD ichthyosiform nevus and their correction through topical application of cholesterol and lovastatin are discussed.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1590/abd1806-4841.20198789