Hesperetin-7-O-rhamnoglucoside ameliorates dichlorvos-facilitated cardiotoxicity in rats by counteracting ionoregulatory, ion pumps, redox, and lipid homeostasis disruptions

• Published in: Toxicology reports 2024-12, Vol.13, p.101698, Article 101698
• Main Authors: Akamo, Adio J., Ojelabi, Adetutu O., Somade, Oluwatobi T., Kehinde, Iyabode A., Taiwo, Adewale M., Olagunju, Boluwatife A., Akinsanya, Mushafau A., Adebisi, Adebisi A., Adekunbi, Tobi S., Adenowo, Abiola F., Anifowose, Florence, Ajagun-Ogunleye, Olufemi M., Eteng, Ofem E., Akintunde, Jacob K., Ugbaja, Regina N.
• Format: Article
• Language: English
• Subjects: Cardiotoxicity; Dichlorvos; Electrolyte; Hesperetin-7-O-rhamnoglucoside; Ion pumps; Lipid; Redox status
• ISSN: 2214-7500; 2214-7500
• DOI: 10.1016/j.toxrep.2024.101698

The contamination of edible agricultural goods with pesticides, including dichlorvos (DVDP), poses a substantial public health risk, promoting severe morbidity and mortality, especially in developing countries. It has been shown that hesperidin (hesperetin-7-O-rhamnoglucoside or Hes-7-RGlc) preserves cytomembrane, redox, and lipid homeostasis; unfortunately, its function on dichlorvos-incited heart damage has not been investigated. This work explored the ameliorative influence of Hes-7-RGlc on DVDP-activated cardiotoxicity. For this end, forty-two rats were randomly appropriated into seven groups (6 rats/group): Control, DVDP alone (8 mg.kg⁻¹day⁻¹), DVDP supplied with either Hes-7-RGlc (50 and 100 mg.kg⁻¹day⁻¹) or the reference medication atropine (0.2 mg.kg⁻¹day⁻¹), and Hes-7-RGlc alone (50 and 10 mg.kg⁻¹day⁻¹) were the seven groups investigated. DVDP was administered orally for seven days, followed by fourteen days of Hes-7-RGlc therapy. Then the rats were euthanized, and their blood and hearts were removed. Hes-7-RGlc chemotherapy substantially (p