Polyhydroxyalkanoate Production by Caenibius tardaugens from Steroidal Endocrine Disruptors

The α-proteobacterium can use estrogens and androgens as the sole carbon source. These compounds are steroidal endocrine disruptors that are found contaminating soil and aquatic ecosystems. Here, we show that , which has been considered as a valuable biocatalyst for aerobic steroidal hormone deconta...

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Bibliographic Details
Published in:Microorganisms (Basel) 2022-03, Vol.10 (4), p.706
Main Authors: Ibero, Juan, Rivero-Buceta, Virginia, García, José Luis, Galán, Beatriz
Format: Article
Language:English
Subjects:
androgen
Androgens
Aquatic ecosystems
Biocompatibility
Biodegradability
Biodegradation
Biotechnology
C. tardaugens
Carbon
Carbon sources
Catabolism
Condensates
Decontamination
Endocrine disruptors
Energy resources
estrogen
Estrogens
Microorganisms
Microscopy
NMR
Nuclear magnetic resonance
Polyester resins
Polyesters
Polyhydroxyalkanoates
Polyhydroxyalkanoic acid
polyhydroxyvalerate
Polymers
Soil contamination
Soil pollution
Steroid hormones
Steroids
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Summary:The α-proteobacterium can use estrogens and androgens as the sole carbon source. These compounds are steroidal endocrine disruptors that are found contaminating soil and aquatic ecosystems. Here, we show that , which has been considered as a valuable biocatalyst for aerobic steroidal hormone decontamination, is also able to produce polyhydroxyalkanoates (PHA), biodegradable and biocompatible polyesters of increasing biotechnological interest as a sustainable alternative to classical oil-derived polymers. Steroid catabolism yields a significant amount of propionyl-CoA that is metabolically directed towards PHA production through condensation into 3-ketovaleryl-CoA, rendering a PHA rich in 3-hydroxyvalerate. To the best of our knowledge, this is the first report where PHAs are produced from steroids as carbon sources.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10040706