Endotracheal enucleation and para‐toluenesulfonamide injection for adenoid cystic carcinoma in the upper trachea: A novel therapeutic approach

We present a case of an adenoid cystic carcinoma (ACC) located in the upper trachea, which resulted in significant airway blockage, that was unsuitable for surgical removal due to concerns about functional impairment. Instead, endotracheal enucleation via rigid bronchoscopy was performed initially,...

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Bibliographic Details
Published in:Thoracic cancer 2024-06, Vol.15 (16), p.1320-1324
Main Authors: Lu, Hsiao‐Hung, Kuo, Shuenn‐Wen
Format: Article
Language:English
Subjects:
Ablation
ablation techniques
adenoid cystic carcinoma
Airway management
airway obstruction
Bronchoscopy
Cancer
Cancer therapies
Case Report
Case Reports
Conflicts of interest
Debridement
Hemoptysis
Larynx
non‐small‐cell lung cancer
para‐toluenesulfonamide
Postoperative period
Radiation therapy
Surgical techniques
Tomography
Tumors
Writing
Citations: Items that this one cites
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Summary:We present a case of an adenoid cystic carcinoma (ACC) located in the upper trachea, which resulted in significant airway blockage, that was unsuitable for surgical removal due to concerns about functional impairment. Instead, endotracheal enucleation via rigid bronchoscopy was performed initially, followed by the injection of a novel tumor ablation agent known as para‐toluenesulfonamide (PTS). We detail the dosing regimen, effectiveness evaluation, and post‐treatment follow‐up. The study highlights the potential of PTS injection as a viable alternative treatment option for patients with ACC who cannot undergo surgical resection and feasibility of lipiodol to monitor treatment effect. This research adds to the existing knowledge on ACC treatment and provides new therapeutic possibilities for patients with tracheal ACC. We present a case of tracheal adenoid cystic carcinoma (ACC) treated with endotracheal enucleation followed by three doses of para‐toluenesulfonamide (PTS)‐lipiodol mixture injection. The treatment resulted in tumor eradication, improved airway patency, and absence of recurrence in 1 year, suggesting PTS as a promising alternative for inoperable ACC.
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.15289