Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as transla...

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Bibliographic Details
Published in:Annals of hepatology 2021-11, Vol.25, p.100538-100538, Article 100538
Main Authors: Wang, Yue-fan, Ge, Chun-mei, Yin, Hao-zan, Dai, Zhi-hui, Dong, Jun-peng, Ji, Man, Yang, Fu
Format: Article
Language:English
Subjects:
Adenosine - analogs & derivatives
Adenosine - physiology
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Chronic liver diseases
HCC
Humans
Liver Neoplasms - etiology
Liver Neoplasms - pathology
N6-methyladenosine
RNA m6A modification
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Summary:N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC.
ISSN:1665-2681
2659-5982
DOI:10.1016/j.aohep.2021.100538