The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy

Few studies have correlated serum biomarkers with renal histology, the gold standard for renal activity, in lupus nephritis (LN). We tested a panel of autoantibodies and complement at the time of kidney biopsy and after treatment. Anti-dsDNA, anti-nucleosome, anti-ribosome P, and anti-C1q antibodies...

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Bibliographic Details
Published in:Journal of immunology research 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Sinico, Renato Alberto, Raffiotta, Francesca, Trezzi, Barbara, Radice, Antonella, Quaglini, Silvana, Moroni, Gabriella, Messa, Piergiorgio
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantibodies - immunology
Biomarkers
Biopsy
Confidence intervals
Female
Humans
Immunology
Kidney - immunology
Kidney - pathology
Lupus
Lupus Nephritis - blood
Lupus Nephritis - diagnosis
Lupus Nephritis - drug therapy
Lupus Nephritis - immunology
Male
Methods
Middle Aged
Mortality
Prognosis
Sediments
Severity of Illness Index
Studies
Treatment Outcome
Young Adult
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Summary:Few studies have correlated serum biomarkers with renal histology, the gold standard for renal activity, in lupus nephritis (LN). We tested a panel of autoantibodies and complement at the time of kidney biopsy and after treatment. Anti-dsDNA, anti-nucleosome, anti-ribosome P, and anti-C1q antibodies and C3/C4 were measured in 107 patients with LN at the time of renal biopsy and after 6–12 months and were correlated with clinical/histological parameters. At multivariate analysis, high titers of anti-C1q antibodies or of anti-dsDNA antibodies ( P = 0.005 , OR = 8.67, CI: 2.03–37.3) were the independent predictors that discriminate proliferative from nonproliferative LN. All the immunological parameters, except anti-ribosome, showed a significant correlation with activity index but not with chronicity index. Only anti-C1q showed a significant correlation with the amount of proteinuria ( R = 0.2 , P = 0.03 ). None of the immunological parameters were predictive of remission at 6 and 12 months. We found that anti-C1q alone or in combination with anti-dsDNA emerged as the most reliable test in differentiating proliferative and nonproliferative LN. Anti-C1q was the only test correlated with the clinical presentation of LN. After treatment, the titre of the autoantibodies was significantly reduced, but none was predictive of remission.
ISSN:2314-8861
2314-7156
DOI:10.1155/2015/106904