Metalloproteomics: principles, challenges and applications to neurodegeneration

Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2013, Vol.5, p.35-35
Main Authors: Lothian, Amber, Hare, Dominic J, Grimm, Rudolf, Ryan, Timothy M, Masters, Colin L, Roberts, Blaine R
Format: Article
Language:English
Subjects:
Biology
Brain research
Enzymes
hyphenated ICP-MS techniques
LC-ICP-MS
Mass spectrometry
Metabolism
Metalloproteomics
Metals
metals in neurodegeneration
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neuroscience
Phosphorylation
Proteins
Proteomics
Quantitative Methods
Science
Scientific imaging
Structure-function relationships
Trace elements
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Summary:Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2013.00035