DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities

Maternal hyperthyroidism is associated with an increased incidence of congenital abnormalities at birth, but it is not clear which of these defects arise from a transient developmental excess of thyroid hormone and which depend on pregnancy stage, antithyroid drug choice, or unwanted subsequent feta...

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Bibliographic Details
Published in:JCI insight 2022-11, Vol.7 (21)
Main Authors: Martinez, M Elena, Pinz, Ilka, Preda, Marilena, Norton, Christine R, Gridley, Thomas, Hernandez, Arturo
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Choanal Atresia
Cleft Palate
Development
Endocrinology
Female
Heart Defects, Congenital
Humans
Hyperthyroidism
Iodide Peroxidase - genetics
Iodide Peroxidase - metabolism
Mice
Mice, Inbred C57BL
Pregnancy
Thyroid Hormones
Thyrotoxicosis - complications
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Summary:Maternal hyperthyroidism is associated with an increased incidence of congenital abnormalities at birth, but it is not clear which of these defects arise from a transient developmental excess of thyroid hormone and which depend on pregnancy stage, antithyroid drug choice, or unwanted subsequent fetal hypothyroidism. To address this issue, we studied a mouse model of comprehensive developmental thyrotoxicosis secondary to a lack of type 3 deiodinase (DIO3). Dio3-/- mice exhibited reduced neonatal viability on most genetic backgrounds and perinatal lethality on a C57BL/6 background. Dio3-/- mice exhibited severe growth retardation during the neonatal period and cartilage loss. Mice surviving after birth manifested brain and cranial dysmorphisms, severe hydrocephalus, choanal atresia, and cleft palate. These abnormalities were noticeable in C57BL/6J Dio3-/- mice at fetal stages, in addition to a thyrotoxic heart with septal defects and thin ventricular walls. Our findings stress the protecting role of DIO3 during development and support the hypothesis that human congenital abnormalities associated with hyperthyroidism during pregnancy are caused by transient thyrotoxicosis before clinical intervention. Our results also suggest thyroid hormone involvement in the etiology of idiopathic pathologies including cleft palate, choanal atresia, Chiari malformations, Kaschin-Beck disease, and Temple and other cranio-encephalic and heart syndromes.
ISSN:2379-3708
2379-3708
DOI:10.1172/jci.insight.161214